Leukocyte cell-derived chemotaxin 1

UniProt data

UniProt name: LECT1_HUMAN (O75829)

Gene name: LECT1; Synonyms=CHMI

Organism: Homo sapiens (Human).

Function: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000269|PubMed:16980969}.

Subcellular location: Chondrosurfactant protein: Endomembrane system {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 45-65, 21 AA, Helical. {ECO:0000255}.

Sequence: 334 AA

10 20 30 40 50 60 MTENSDKVPI ALVGPDDVEF CSPPAYATLT VKPSSPARLL KVGAVVLISG AVLLLFGAIG 70 80 90 100 110 120 AFYFWKGSDS HIYNVHYTMS INGKLQDGSM EIDAGNNLET FKMGSGAEEA IAVNDFQNGI 130 140 150 160 170 180 TGIRFAGGEK CYIKAQVKAR IPEVGAVTKQ SISSKLEGKI MPVKYEENSL IWVAVDQPVK 190 200 210 220 230 240 DNSFLSSKVL ELCGDLPIFW LKPTYPKEIQ RERREVVRKI VPTTTKRPHS GPRSNPGAGR 250 260 270 280 290 300 LNNETRPSVQ EDSQAFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL 310 320 330 GGYYPWPYNY QGCRSACRVI MPCSWWVARI LGMV

CATM prediction

The sequence of LECT1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          50        60       
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 VGAVVLISGAVLLLFGAIGAFYFWKGS 7.3 -38.1° 3.2 34.8 -26.1
Model 2 VGAVVLISGAVLLLFGAIGAFYFWKGS 7.0 -52.0° 1.8 34.7 -12.6
Model 3 VGAVVLISGAVLLLFGAIGAFYFWKGS 7.2 -49.1° 2.9 32.0 -7.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 54, LEU, HA A, 53, LEU, O 3.43Å
B, 57, GLY, HA1 A, 54, LEU, O 3.35Å
A, 54, LEU, HA B, 53, LEU, O 3.43Å
A, 57, GLY, HA1 B, 54, LEU, O 3.35Å