UniProt data
UniProt name: ITA10_HUMAN (O75578)
Gene name: ITGA10; ORFNames=UNQ468/PRO827
Organism: Homo sapiens (Human).
Function: Integrin alpha-10/beta-1 is a receptor for collagen.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 1123-1145, 23 AA, Helical. {ECO:0000255}.
Sequence: 1167 AA
10 20 30 40 50 60
MELPFVTHLF LPLVFLTGLC SPFNLDEHHP RLFPGPPEAE FGYSVLQHVG GGQRWMLVGA
70 80 90 100 110 120
PWDGPSGDRR GDVYRCPVGG AHNAPCAKGH LGDYQLGNSS HPAVNMHLGM SLLETDGDGG
130 140 150 160 170 180
FMACAPLWSR ACGSSVFSSG ICARVDASFQ PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP
190 200 210 220 230 240
WSEVQTFLRR LVGKLFIDPE QIQVGLVQYG ESPVHEWSLG DFRTKEEVVR AAKNLSRREG
250 260 270 280 290 300
RETKTAQAIM VACTEGFSQS HGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY
310 320 330 340 350 360
GIAVLGHYLR RQRDPSSFLR EIRTIASDPD ERFFFNVTDE AALTDIVDAL GDRIFGLEGS
370 380 390 400 410 420
HAENESSFGL EMSQIGFSTH RLKDGILFGM VGAYDWGGSV LWLEGGHRLF PPRMALEDEF
430 440 450 460 470 480
PPALQNHAAY LGYSVSSMLL RGGRRLFLSG APRFRHRGKV IAFQLKKDGA VRVAQSLQGE
490 500 510 520 530 540
QIGSYFGSEL CPLDTDRDGT TDVLLVAAPM FLGPQNKETG RVYVYLVGQQ SLLTLQGTLQ
550 560 570 580 590 600
PEPPQDARFG FAMGALPDLN QDGFADVAVG APLEDGHQGA LYLYHGTQSG VRPHPAQRIA
610 620 630 640 650 660
AASMPHALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVHLTP SLEVTPQAIS
670 680 690 700 710 720
VVQRDCRRRG QEAVCLTAAL CFQVTSRTPG RWDHQFYMRF TASLDEWTAG ARAAFDGSGQ
730 740 750 760 770 780
RLSPRRLRLS VGNVTCEQLH FHVLDTSDYL RPVALTVTFA LDNTTKPGPV LNEGSPTSIQ
790 800 810 820 830 840
KLVPFSKDCG PDNECVTDLV LQVNMDIRGS RKAPFVVRGG RRKVLVSTTL ENRKENAYNT
850 860 870 880 890 900
SLSLIFSRNL HLASLTPQRE SPIKVECAAP SAHARLCSVG HPVFQTGAKV TFLLEFEFSC
910 920 930 940 950 960
SSLLSQVFVK LTASSDSLER NGTLQDNTAQ TSAYIQYEPH LLFSSESTLH RYEVHPYGTL
970 980 990 1000 1010 1020
PVGPGPEFKT TLRVQNLGCY VVSGLIISAL LPAVAHGGNY FLSLSQVITN NASCIVQNLT
1030 1040 1050 1060 1070 1080
EPPGPPVHPE ELQHTNRLNG SNTQCQVVRC HLGQLAKGTE VSVGLLRLVH NEFFRRAKFK
1090 1100 1110 1120 1130 1140
SLTVVSTFEL GTEEGSVLQL TEASRWSESL LEVVQTRPIL ISLWILIGSV LGGLLLLALL
1150 1160
VFCLWKLGFF AHKKIPEEEK REEKLEQ
CATM prediction
The sequence of ITA10_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 1120 1130 1140 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | LISLWILIGSVLGGLLLLALLVFCLWKLG | 6.7 | -47.7° | -0.0 | 38.1 | -21.0 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 1128, GLY, HA1 | A, 1125, ILE, O | 3.01Å |
| B, 1129, SER, HA | A, 1128, GLY, O | 2.73Å |
| B, 1132, GLY, HA1 | A, 1129, SER, O | 3.24Å |
| A, 1128, GLY, HA1 | B, 1125, ILE, O | 3.01Å |
| A, 1129, SER, HA | B, 1128, GLY, O | 2.73Å |
| A, 1132, GLY, HA1 | B, 1129, SER, O | 3.24Å |