Ectonucleoside triphosphate diphosphohydrolase 6

UniProt data

UniProt name: ENTP6_HUMAN (O75354)

Gene name: ENTPD6; Synonyms=CD39L2, IL6ST2

Organism: Homo sapiens (Human).

Function: Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity). {ECO:0000250}.

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Note=But also occurs in a soluble extracellular form.

Transmembrane domains:

  1. 40-60, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 484 AA

10 20 30 40 50 60 MKKGIRYETS RKTSYIFQQP QHGPWQTRMR KISNHGSLRV AKVAYPLGLC VGVFIYVAYI 70 80 90 100 110 120 KWHRATATQA FFSITRAAPG ARWGQQAHSP LGTAADGHEV FYGIMFDAGS TGTRVHVFQF 130 140 150 160 170 180 TRPPRETPTL THETFKALKP GLSAYADDVE KSAQGIRELL DVAKQDIPFD FWKATPLVLK 190 200 210 220 230 240 ATAGLRLLPG EKAQKLLQKV KKVFKASPFL VGDDCVSIMN GTDEGVSAWI TINFLTGSLK 250 260 270 280 290 300 TPGGSSVGML DLGGGSTQIA FLPRVEGTLQ ASPPGYLTAL RMFNRTYKLY SYSYLGLGLM 310 320 330 340 350 360 SARLAILGGV EGQPAKDGKE LVSPCLSPSF KGEWEHAEVT YRVSGQKAAA SLHELCAARV 370 380 390 400 410 420 SEVLQNRVHR TEEVKHVDFY AFSYYYDLAA GVGLIDAEKG GSLVVGDFEI AAKYVCRTLE 430 440 450 460 470 480 TQPQSSPFSC MDLTYVSLLL QEFGFPRSKV LKLTRKIDNV ETSWALGAIF HYIDSLNRQK SPAS

CATM prediction

The sequence of ENTP6_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     40        50        60  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SLRVAKVAYALGLCVGVFIYVAYIKWH 6.8 -34.1° 1.6 56.9 -30.7
Model 2 SLRVAKVAYALGLCVGVFIYVAYIKWH 7.0 -51.9° 1.4 56.8 -9.8
Prolines* SLRVAKVAYPLGLCVGVFIYVAYIKWH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 45, TYR, HA A, 44, ALA, O 2.82Å
B, 48, GLY, HA1 A, 45, TYR, O 3.04Å
B, 49, LEU, HA A, 48, GLY, O 3.23Å
A, 45, TYR, HA B, 44, ALA, O 2.82Å
A, 48, GLY, HA1 B, 45, TYR, O 3.04Å
A, 49, LEU, HA B, 48, GLY, O 3.23Å