Leucine-rich repeat neuronal protein 2

UniProt data

UniProt name: LRRN2_HUMAN (O75325)

Gene name: LRRN2; Synonyms=GAC1, LRRN5; ORFNames=UNQ256/PRO293

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 631-651, 21 AA, Helical. {ECO:0000255}.

Sequence: 713 AA

10 20 30 40 50 60 MRLLVAPLLL AWVAGATAAV PVVPWHVPCP PQCACQIRPW YTPRSSYREA TTVDCNDLFL 70 80 90 100 110 120 TAVPPALPAG TQTLLLQSNS IVRVDQSELG YLANLTELDL SQNSFSDARD CDFHALPQLL 130 140 150 160 170 180 SLHLEENQLT RLEDHSFAGL ASLQELYLNH NQLYRIAPRA FSGLSNLLRL HLNSNLLRAI 190 200 210 220 230 240 DSRWFEMLPN LEILMIGGNK VDAILDMNFR PLANLRSLVL AGMNLREISD YALEGLQSLE 250 260 270 280 290 300 SLSFYDNQLA RVPRRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS 310 320 330 340 350 360 IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL HQQTVESLPN 370 380 390 400 410 420 LQEVGLHGNP IRCDCVIRWA NATGTRVRFI EPQSTLCAEP PDLQRLPVRE VPFREMTDHC 430 440 450 460 470 480 LPLISPRSFP PSLQVASGES MVLHCRALAE PEPEIYWVTP AGLRLTPAHA GRRYRVYPEG 490 500 510 520 530 540 TLELRRVTAE EAGLYTCVAQ NLVGADTKTV SVVVGRALLQ PGRDEGQGLE LRVQETHPYH 550 560 570 580 590 600 ILLSWVTPPN TVSTNLTWSS ASSLRGQGAT ALARLPRGTH SYNITRLLQA TEYWACLQVA 610 620 630 640 650 660 FADAHTQLAC VWARTKEATS CHRALGDRPG LIAILALAVL LLAAGLAAHL GTGQPRKGVG 670 680 690 700 710 GRRPLPPAWA FWGWSAPSVR VVSAPLVLPW NPGRKLPRSS EGETLLPPLS QNS

CATM prediction

The sequence of LRRN2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    630       640       650  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 RAGLIAILALAVLLLAAGLAAHLGTGQ 7.0 -37.0° 0.0 37.0 -5.1
Prolines* RPGLIAILALAVLLLAAGLAAHLGTGQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 648, ALA, HA A, 647, ALA, O 2.95Å
B, 651, GLY, HA1 A, 648, ALA, O 3.42Å
A, 648, ALA, HA B, 647, ALA, O 2.95Å
A, 651, GLY, HA1 B, 648, ALA, O 3.42Å