Stannin

UniProt data

UniProt name: SNN_HUMAN (O75324)

Gene name: SNN

Organism: Homo sapiens (Human).

Function: Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288). {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:27015288}.

Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:16246365}; Single-pass membrane protein {ECO:0000269|PubMed:16246365}.

Transmembrane domains:

  1. 11-31, 21 AA, Helical. {ECO:0000255}.

Sequence: 88 AA

10 20 30 40 50 60 MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI VGDGETKEPF 70 80 LLVQYSAKGP CVERKAKLMT PNGPEVHG

CATM prediction

The sequence of SNN_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    10        20        30   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ATTGVVTVIVILIAIAALGALILGCWC 7.3 -34.0° 1.8 40.9 -11.6
Model 2 ATTGVVTVIVILIAIAALGALILGCWC 7.2 -52.8° 3.1 34.1 -11.0
Prolines* PTTGVVTVIVILIAIAALGALILGCWC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 24, ALA, HA A, 23, ALA, O 3.48Å
B, 28, LEU, HA A, 27, ALA, O 3.30Å
A, 24, ALA, HA B, 23, ALA, O 3.48Å
A, 28, LEU, HA B, 27, ALA, O 3.30Å