UDP-glucuronosyltransferase 2B11

UniProt data

UniProt name: UDB11_HUMAN (O75310)

Gene name: UGT2B11

Organism: Homo sapiens (Human).

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Subcellular location: Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 493-513, 21 AA, Helical. {ECO:0000255}.

Sequence: 529 AA

10 20 30 40 50 60 MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA 70 80 90 100 110 120 SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY 130 140 150 160 170 180 DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI 190 200 210 220 230 240 ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL 250 260 270 280 290 300 GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG 310 320 330 340 350 360 ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN 370 380 390 400 410 420 DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM 430 440 450 460 470 480 SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA 490 500 510 520 HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD

CATM prediction

The sequence of UDB11_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  490       500       510    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 SLDVIGFLLACVATVIFIITKFCLFCF 7.0 -44.0° 1.8 45.0 -8.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 496, PHE, HA A, 495, GLY, O 3.24Å
A, 496, PHE, HA B, 495, GLY, O 3.24Å