Cadherin-16

UniProt data

UniProt name: CAD16_HUMAN (O75309)

Gene name: CDH16; ORFNames=UNQ695/PRO1340

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 787-807, 21 AA, Helical. {ECO:0000255}.

Sequence: 829 AA

10 20 30 40 50 60 MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG AEGQIVLSGD 70 80 90 100 110 120 SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM QDGHVLWGPQ PVLVHVKDEN 130 140 150 160 170 180 DQVPHFSQAI YRARLSRGTR PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF 190 200 210 220 230 240 QLEPRLGALA LSPKGSTSLD HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS 250 260 270 280 290 300 LEPIHLAENL KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA 310 320 330 340 350 360 EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA 370 380 390 400 410 420 EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM 430 440 450 460 470 480 DLAGAEGGFS STCEVEVAVT DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE 490 500 510 520 530 540 PAFRLMDFAI ERGDTEGTFG LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG 550 560 570 580 590 600 PGPGPGATAT VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL 610 620 630 640 650 660 VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP 670 680 690 700 710 720 PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT 730 740 750 760 770 780 LNGSHAYLTL ALHWVEPREH IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM 790 800 810 820 PTKLSAVGIL VGTLVAIGIF LILIFTHWTM SRKKDPDQPA DSVPLKATV

CATM prediction

The sequence of CAD16_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        790       800       8
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 LSAVGILVGTLVAIGIFLILIFTHWTM 6.4 -46.9° 3.3 54.1 -31.2
Model 2 LSAVGILVGTLVAIGIFLILIFTHWTM 6.9 -28.0° 2.4 50.0 -22.7
Model 3 LSAVGILVGTLVAIGIFLILIFTHWTM 7.0 -40.0° 4.0 38.0 -7.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 789, ILE, HA A, 788, GLY, O 2.43Å
B, 792, GLY, HA1 A, 789, ILE, O 2.57Å
B, 793, THR, HA A, 792, GLY, O 3.42Å
A, 789, ILE, HA B, 788, GLY, O 2.43Å
A, 792, GLY, HA1 B, 789, ILE, O 2.57Å
A, 793, THR, HA B, 792, GLY, O 3.42Å