Small integral membrane protein 24

UniProt data

UniProt name: SIM24_HUMAN (O75264)

Gene name: SMIM24; Synonyms=C19orf77; ORFNames=HSPC323

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 31-51, 21 AA, Helical. {ECO:0000255}.

Sequence: 130 AA

10 20 30 40 50 60 METLGALLVL EFLLLSPVEA QQATEHRLKP WLVGLAAVVG FLFIVYLVLL ANRLWCSKAR 70 80 90 100 110 120 AEDEEETTFR MESNLYQDQS EDKREKKEAK EKEEKRKKEK KTAKEGESNL GLDLEEKEPG DHERAKSTVM

CATM prediction

The sequence of SIM24_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    30        40        50   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LKAWLVGLAAVVGFLFIVYLVLLANRL 7.1 -54.0° 4.8 41.1 -2.2
Model 2 LKAWLVGLAAVVGFLFIVYLVLLANRL 7.1 -53.9° 4.8 41.0 -2.1
Prolines* LKPWLVGLAAVVGFLFIVYLVLLANRL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 37, ALA, HA A, 36, ALA, O 3.04Å
B, 40, GLY, HA1 A, 37, ALA, O 3.44Å
A, 37, ALA, HA B, 36, ALA, O 3.04Å
A, 40, GLY, HA1 B, 37, ALA, O 3.44Å