ICOS ligand

UniProt data

UniProt name: ICOSL_HUMAN (O75144)

Gene name: ICOSLG; Synonyms=B7H2, B7RP1, ICOSL, KIAA0653

Organism: Homo sapiens (Human).

Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 257-277, 21 AA, Helical. {ECO:0000255}.

Sequence: 302 AA

10 20 30 40 50 60 MRLGSPGLLF LLFSSLRADT QEKEVRAMVG SDVELSCACP EGSRFDLNDV YVYWQTSESK 70 80 90 100 110 120 TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL FNVTPQDEQK FHCLVLSQSL 130 140 150 160 170 180 GFQEVLSVEV TLHVAANFSV PVVSAPHSPS QDELTFTCTS INGYPRPNVY WINKTDNSLL 190 200 210 220 230 240 DQALQNDTVF LNMRGLYDVV SVLRIARTPS VNIGCCIENV LLQQNLTVGS QTGNDIGERD 250 260 270 280 290 300 KITENPVSTG EKNAATWSIL AVLCLLVVVA VAIGWVCRDR CLQHSYAGAW AVSPETELTG HV

CATM prediction

The sequence of ICOSL_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        260       270       2
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 AATWSILAVLCLLVVVAVAIGWVCRDR 7.3 -51.1° 3.3 48.0 -6.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 271, VAL, HA A, 270, ALA, O 3.27Å
B, 274, GLY, HA1 A, 271, VAL, O 3.34Å
A, 271, VAL, HA B, 270, ALA, O 3.27Å
A, 274, GLY, HA1 B, 271, VAL, O 3.34Å