UniProt data
UniProt name: ADA11_HUMAN (O75078)
Gene name: ADAM11; Synonyms=MDC
Organism: Homo sapiens (Human).
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 735-755, 21 AA, Helical. {ECO:0000255}.
Sequence: 769 AA
10 20 30 40 50 60
MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP SRLVRESSGG
70 80 90 100 110 120
EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD LELNHHLLSS QYVERHFSRE
130 140 150 160 170 180
GTTQHSTGAG DHCYYQGKLR GNPHSFAALS TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP
190 200 210 220 230 240
QGPLPHLIYR TPLLPDPLGC REPGCLFAVP AQSAPPNRPR LRRKRQVRRG HPTVHSETKY
250 260 270 280 290 300
VELIVINDHQ LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ
310 320 330 340 350 360
VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS LSHGGGVNEY
370 380 390 400 410 420
GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG CIMEDTGFYL PRKFSRCSID
430 440 450 460 470 480
EYNQFLQEGG GSCLFNKPLK LLDPPECGNG FVEAGEECDC GSVQECSRAG GNCCKKCTLT
490 500 510 520 530 540
HDAMCSDGLC CRRCKYEPRG VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG
550 560 570 580 590 600
RCYGGRCKTR DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF
610 620 630 640 650 660
LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE DGTACGPNML
670 680 690 700 710 720
CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC QPDWTGKDCS IHNPLPTSPP
730 740 750 760
TGETERYKGP SGTNIIIGSI AGAVLVAAIV LGGTGWGFKN IRRGRSGGA
CATM prediction
The sequence of ADA11_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 740 750 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GTNIIIGSIAGAVLVAAIVLGGTGWGF | 6.7 | -48.9° | 1.8 | 44.8 | -22.6 |
| Model 2 | GTNIIIGSIAGAVLVAAIVLGGTGWGF | 6.7 | -47.9° | 5.1 | 38.9 | -21.1 |
| Model 3 | GTNIIIGSIAGAVLVAAIVLGGTGWGF | 6.8 | -53.0° | 1.9 | 44.9 | -16.9 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 749, ILE, HA | A, 748, ALA, O | 3.03Å |
| B, 752, GLY, HA1 | A, 749, ILE, O | 2.69Å |
| B, 753, GLY, HA2 | A, 752, GLY, O | 3.15Å |
| A, 749, ILE, HA | B, 748, ALA, O | 3.03Å |
| A, 752, GLY, HA1 | B, 749, ILE, O | 2.69Å |
| A, 753, GLY, HA2 | B, 752, GLY, O | 3.15Å |
