UniProt data
UniProt name: ADA23_HUMAN (O75077)
Gene name: ADAM23; Synonyms=MDC3
Organism: Homo sapiens (Human).
Function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
Subcellular location: Isoform Gamma: Secreted.
Transmembrane domains:
- 793-813, 21 AA, Helical. {ECO:0000255}.
Sequence: 832 AA
10 20 30 40 50 60
MKPPGSSSRQ PPLAGCSLAG ASCGPQRGPA GSVPASAPAR TPPCRLLLVL LLLPPLAASS
70 80 90 100 110 120
RPRAWGAAAP SAPHWNETAE KNLGVLADED NTLQQNSSSN ISYSNAMQKE ITLPSRLIYY
130 140 150 160 170 180
INQDSESPYH VLDTKARHQQ KHNKAVHLAQ ASFQIEAFGS KFILDLILNN GLLSSDYVEI
190 200 210 220 230 240
HYENGKPQYS KGGEHCYYHG SIRGVKDSKV ALSTCNGLHG MFEDDTFVYM IEPLELVHDE
250 260 270 280 290 300
KSTGRPHIIQ KTLAGQYSKQ MKNLTMERGD QWPFLSELQW LKRRKRAVNP SRGIFEEMKY
310 320 330 340 350 360
LELMIVNDHK TYKKHRSSHA HTNNFAKSVV NLVDSIYKEQ LNTRVVLVAV ETWTEKDQID
370 380 390 400 410 420
ITTNPVQMLH EFSKYRQRIK QHADAVHLIS RVTFHYKRSS LSYFGGVCSR TRGVGVNEYG
430 440 450 460 470 480
LPMAVAQVLS QSLAQNLGIQ WEPSSRKPKC DCTESWGGCI MEETGVSHSR KFSKCSILEY
490 500 510 520 530 540
RDFLQRGGGA CLFNRPTKLF EPTECGNGYV EAGEECDCGF HVECYGLCCK KCSLSNGAHC
550 560 570 580 590 600
SDGPCCNNTS CLFQPRGYEC RDAVNECDIT EYCTGDSGQC PPNLHKQDGY ACNQNQGRCY
610 620 630 640 650 660
NGECKTRDNQ CQYIWGTKAA GSDKFCYEKL NTEGTEKGNC GKDGDRWIQC SKHDVFCGFL
670 680 690 700 710 720
LCTNLTRAPR IGQLQGEIIP TSFYHQGRVI DCSGAHVVLD DDTDVGYVED GTPCGPSMMC
730 740 750 760 770 780
LDRKCLQIQA LNMSSCPLDS KGKVCSGHGV CSNEATCICD FTWAGTDCSI RDPVRNLHPP
790 800 810 820 830
KDEGPKGPSA TNLIIGSIAG AILVAAIVLG GTGWGFKNVK KRRFDPTQQG PI
CATM prediction
The sequence of ADA23_HUMAN returned 4 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 790 800 810 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | ATNLIIGSIAGAILVAAIVLGGTGWGF | 6.6 | -47.8° | 5.1 | 39.2 | -21.3 |
| Model 2 | ATNLIIGSIAGAILVAAIVLGGTGWGF | 6.7 | -48.9° | 1.8 | 45.0 | -20.6 |
| Model 3 | ATNLIIGSIAGAILVAAIVLGGTGWGF | 6.9 | -23.0° | 4.2 | 54.0 | -17.2 |
| Model 4 | ATNLIIGSIAGAILVAAIVLGGTGWGF | 6.9 | -36.0° | 5.1 | 45.0 | -10.6 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 796, GLY, HA1 | A, 793, LEU, O | 3.13Å |
| B, 797, SER, HA | A, 796, GLY, O | 2.49Å |
| B, 800, GLY, HA1 | A, 797, SER, O | 2.82Å |
| A, 796, GLY, HA1 | B, 793, LEU, O | 3.13Å |
| A, 797, SER, HA | B, 796, GLY, O | 2.49Å |
| A, 800, GLY, HA1 | B, 797, SER, O | 2.82Å |
