Low-density lipoprotein receptor-related protein 3

UniProt data

UniProt name: LRP3_HUMAN (O75074)

Gene name: LRP3

Organism: Homo sapiens (Human).

Function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.

Transmembrane domains:

  1. 497-517, 21 AA, Helical. {ECO:0000255}.

Sequence: 770 AA

10 20 30 40 50 60 MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP 70 80 90 100 110 120 AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC 130 140 150 160 170 180 GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP 190 200 210 220 230 240 GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC 250 260 270 280 290 300 GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL 310 320 330 340 350 360 RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA 370 380 390 400 410 420 TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ 430 440 450 460 470 480 YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC 490 500 510 520 530 540 QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL 550 560 570 580 590 600 EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS 610 620 630 640 650 660 RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST 670 680 690 700 710 720 RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP 730 740 750 760 CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC

CATM prediction

The sequence of LRP3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        500       510       5
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 ARKVITAALIGSLVCGLLLVIALGCAF 6.6 -51.2° 2.4 45.0 -19.1
Prolines* PRKVITAALIGSLVCGLLLVIALGCAF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 501, ALA, HA A, 500, ALA, O 2.83Å
B, 504, GLY, HA1 A, 501, ALA, O 2.59Å
B, 505, SER, HA A, 504, GLY, O 3.44Å
A, 501, ALA, HA B, 500, ALA, O 2.83Å
A, 504, GLY, HA1 B, 501, ALA, O 2.59Å
A, 505, SER, HA B, 504, GLY, O 3.44Å