Syndecan-3

UniProt data

UniProt name: SDC3_HUMAN (O75056)

Gene name: SDC3; Synonyms=KIAA0468

Organism: Homo sapiens (Human).

Function: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. {ECO:0000250, ECO:0000269|PubMed:11527150}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 388-408, 21 AA, Helical. {ECO:0000255}.

Sequence: 442 AA

10 20 30 40 50 60 MKPGPPHRAG AAHGAGAGAG AAAGPGARGL LLPPLLLLLL AGRAAGAQRW RSENFERPVD 70 80 90 100 110 120 LEGSGDDDSF PDDELDDLYS GSGSGYFEQE SGIETAMRFS PDVALAVSTT PAVLPTTNIQ 130 140 150 160 170 180 PVGTPFEELP SERPTLEPAT SPLVVTEVPE EPSQRATTVS TTMATTAATS TGDPTVATVP 190 200 210 220 230 240 ATVATATPST PAAPPFTATT AVIRTTGVRR LLPLPLTTVA TARATTPEAP SPPTTAAVLD 250 260 270 280 290 300 TEAPTPRLVS TATSRPRALP RPATTQEPDI PERSTLPLGT TAPGPTEVAQ TPTPETFLTT 310 320 330 340 350 360 IRDEPEVPVS GGPSGDFELP EEETTQPDTA NEVVAVGGAA AKASSPPGTL PKGARPGPGL 370 380 390 400 410 420 LDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA AFLVTLLIYR MKKKDEGSYT 430 440 LEEPKQASVT YQKPDKQEEF YA

CATM prediction

The sequence of SDC3_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       390       400       41
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 VLVAVIVGGVVGALFAAFLVTLLIYRM 6.4 -43.0° 5.4 60.2 -41.4
Model 2 VLVAVIVGGVVGALFAAFLVTLLIYRM 6.3 -41.1° 3.4 38.0 -37.0
Model 3 VLVAVIVGGVVGALFAAFLVTLLIYRM 6.4 -55.1° 0.9 49.8 -24.5
Model 4 VLVAVIVGGVVGALFAAFLVTLLIYRM 7.3 -28.9° 0.2 58.8 -16.5
Model 5 VLVAVIVGGVVGALFAAFLVTLLIYRM 7.3 -52.1° 0.6 47.9 -15.6
Model 6 VLVAVIVGGVVGALFAAFLVTLLIYRM 7.4 -36.0° 3.1 45.8 -8.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 389, VAL, HA A, 388, ALA, O 3.01Å
B, 392, GLY, HA1 A, 389, VAL, O 2.66Å
B, 393, GLY, HA2 A, 392, GLY, O 2.45Å
B, 396, GLY, HA1 A, 393, GLY, O 3.38Å
A, 389, VAL, HA B, 388, ALA, O 3.01Å
A, 392, GLY, HA1 B, 389, VAL, O 2.66Å
A, 393, GLY, HA2 B, 392, GLY, O 2.45Å
A, 396, GLY, HA1 B, 393, GLY, O 3.38Å