Plexin-A2

UniProt data

UniProt name: PLXA2_HUMAN (O75051)

Gene name: PLXNA2; Synonyms=KIAA0463, OCT, PLXN2; ORFNames=UNQ209/PRO235

Organism: Homo sapiens (Human).

Function: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:10520995}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 1238-1258, 21 AA, Helical. {ECO:0000255}.

Sequence: 1894 AA

10 20 30 40 50 60 MEQRRPWPRA LEVDSRSVVL LSVVWVLLAP PAAGMPQFST FHSENRDWTF NHLTVHQGTG 70 80 90 100 110 120 AVYVGAINRV YKLTGNLTIQ VAHKTGPEED NKSCYPPLIV QPCSEVLTLT NNVNKLLIID 130 140 150 160 170 180 YSENRLLACG SLYQGVCKLL RLDDLFILVE PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG 190 200 210 220 230 240 KLFIGTAVDG KQDYFPTLSS RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD 250 260 270 280 290 300 IFYIYGFASG GFVYFLTVQP ETPEGVAINS AGDLFYTSRI VRLCKDDPKF HSYVSLPFGC 310 320 330 340 350 360 TRAGVEYRLL QAAYLAKPGD SLAQAFNITS QDDVLFAIFS KGQKQYHHPP DDSALCAFPI 370 380 390 400 410 420 RAINLQIKER LQSCYQGEGN LELNWLLGKD VQCTKAPVPI DDNFCGLDIN QPLGGSTPVE 430 440 450 460 470 480 GLTLYTTSRD RMTSVASYVY NGYSVVFVGT KSGKLKKIRA DGPPHGGVQY EMVSVLKDGS 490 500 510 520 530 540 PILRDMAFSI DQRYLYVMSE RQVTRVPVES CEQYTTCGEC LSSGDPHCGW CALHNMCSRR 550 560 570 580 590 600 DKCQQAWEPN RFAASISQCV SLAVHPSSIS VSEHSRLLSL VVSDAPDLSA GIACAFGNLT 610 620 630 640 650 660 EVEGQVSGSQ VICISPGPKD VPVIPLDQDW FGLELQLRSK ETGKIFVSTE FKFYNCSAHQ 670 680 690 700 710 720 LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINISED CPQLVPTEEI LIPVGEVKPI 730 740 750 760 770 780 TLKARNLPQP QSGQRGYECV LNIQGAIHRV PALRFNSSSV QCQNSSYQYD GMDISNLAVD 790 800 810 820 830 840 FAVVWNGNFI IDNPQDLKVH LYKCAAQRES CGLCLKADRK FECGWCSGER RCTLHQHCTS 850 860 870 880 890 900 PSSPWLDWSS HNVKCSNPQI TEILTVSGPP EGGTRVTIHG VNLGLDFSEI AHHVQVAGVP 910 920 930 940 950 960 CTPLPGEYII AEQIVCEMGH ALVGTTSGPV RLCIGECKPE FMTKSHQQYT FVNPSVLSLN 970 980 990 1000 1010 1020 PIRGPESGGT MVTITGHYLG AGSSVAVYLG NQTCEFYGRS MSEIVCVSPP SSNGLGPVPV 1030 1040 1050 1060 1070 1080 SVSVDRAHVD SNLQFEYIDD PRVQRIEPEW SIASGHTPLT ITGFNLDVIQ EPRIRVKFNG 1090 1100 1110 1120 1130 1140 KESVNVCKVV NTTTLTCLAP SLTTDYRPGL DTVERPDEFG FVFNNVQSLL IYNDTKFIYY 1150 1160 1170 1180 1190 1200 PNPTFELLSP TGVLDQKPGS PIILKGKNLC PPASGGAKLN YTVLIGETPC AVTVSETQLL 1210 1220 1230 1240 1250 1260 CEPPNLTGQH KVMVHVGGMV FSPGSVSVIS DSLLTLPAIV SIAAGGSLLL IIVIIVLIAY 1270 1280 1290 1300 1310 1320 KRKSRENDLT LKRLQMQMDN LESRVALECK EAFAELQTDI NELTSDLDRS GIPYLDYRTY 1330 1340 1350 1360 1370 1380 AMRVLFPGIE DHPVLRELEV QGNGQQHVEK ALKLFAQLIN NKVFLLTFIR TLELQRSFSM 1390 1400 1410 1420 1430 1440 RDRGNVASLI MTGLQGRLEY ATDVLKQLLS DLIDKNLENK NHPKLLLRRT ESVAEKMLTN 1450 1460 1470 1480 1490 1500 WFAFLLHKFL KECAGEPLFM LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIEYKTL 1510 1520 1530 1540 1550 1560 ILNCVNPDNE NSPEIPVKVL NCDTITQVKE KILDAVYKNV PYSQRPRAVD MDLEWRQGRI 1570 1580 1590 1600 1610 1620 ARVVLQDEDI TTKIEGDWKR LNTLMHYQVS DRSVVALVPK QTSSYNIPAS ASISRTSISR 1630 1640 1650 1660 1670 1680 YDSSFRYTGS PDSLRSRAPM ITPDLESGVK VWHLVKNHDH GDQKEGDRGS KMVSEIYLTR 1690 1700 1710 1720 1730 1740 LLATKGTLQK FVDDLFETLF STVHRGSALP LAIKYMFDFL DEQADRHSIH DTDVRHTWKS 1750 1760 1770 1780 1790 1800 NCLPLRFWVN VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY 1810 1820 1830 1840 1850 1860 AKDIPSYKSW VERYYADIAK LPAISDQDMN AYLAEQSRLH AVEFNMLSAL NEIYSYVSKY 1870 1880 1890 SEELIGALEQ DEQARRQRLA YKVEQLINAM SIES

CATM prediction

The sequence of PLXA2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       1240      1250      12
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TLAAIVSIAAGGSLLLIIVIIVLIAYK 7.3 -53.7° 3.6 48.9 -6.0
Prolines* TLPAIVSIAAGGSLLLIIVIIVLIAYK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1238, ALA, HA A, 1241, SER, OG 3.04Å
B, 1242, ILE, HA A, 1241, SER, O 3.24Å
B, 1245, GLY, HA1 A, 1242, ILE, O 3.37Å
A, 1238, ALA, HA B, 1241, SER, OG 3.04Å
A, 1242, ILE, HA B, 1241, SER, O 3.24Å
A, 1245, GLY, HA1 B, 1242, ILE, O 3.37Å