Leukocyte immunoglobulin-like receptor subfamily B member 3

UniProt data

UniProt name: LIRB3_HUMAN (O75022)

Gene name: LILRB3; Synonyms=ILT5, LIR3

Organism: Homo sapiens (Human).

Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). {ECO:0000250|UniProtKB:P97484}.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 444-464, 21 AA, Helical. {ECO:0000255}.

Sequence: 631 AA

10 20 30 40 50 60 MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSQEAQEYRL 70 80 90 100 110 120 HKEGSPEPLD RNNPLEPKNK ARFSIPSMTE HHAGRYRCHY YSSAGWSEPS DPLEMVMTGA 130 140 150 160 170 180 YSKPTLSALP SPVVASGGNM TLRCGSQKGY HHFVLMKEGE HQLPRTLDSQ QLHSRGFQAL 190 200 210 220 230 240 FPVGPVTPSH RWRFTCYYYY TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS 250 260 270 280 290 300 LTLQCGSDVG YNRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH 310 320 330 340 350 360 NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ FDTFLLTKEG 370 380 390 400 410 420 AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY SSNPHLLSHP SEPLELVVSG 430 440 450 460 470 480 HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT 490 500 510 520 530 540 DFQRPAGAAE TEPKDRGLLR RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA 550 560 570 580 590 600 VTYAPVKHSS PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS 610 620 630 LTLRRKATEP PPSQEGEPPA EPSIYATLAI H

CATM prediction

The sequence of LIRB3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           450       460     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 YLEVLIGVSVAFVLLLFLLLFLLLRRQ 7.2 -46.0° 2.7 47.0 -17.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 447, GLY, HA1 A, 444, VAL, O 3.18Å
A, 447, GLY, HA1 B, 444, VAL, O 3.18Å