Sodium channel subunit beta-2

UniProt data

UniProt name: SCN2B_HUMAN (O60939)

Gene name: SCN2B; ORFNames=UNQ326/PRO386

Organism: Homo sapiens (Human).

Function: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 160-180, 21 AA, Helical. {ECO:0000255}.

Sequence: 215 AA

10 20 30 40 50 60 MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC TFNSCYTVNH 70 80 90 100 110 120 KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE FSGNPSKYDV SVMLRNVQPE 130 140 150 160 170 180 DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE PPERDSTVAV IVGASVGGFL AVVILVLMVV 190 200 210 KCVRRKKEQK LSTDDLKTEE EGKTDGEGNP DDGAK

CATM prediction

The sequence of SCN2B_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     160       170       180 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 TVAVIVGASVGGFLAVVILVLMVVKCV 6.4 -42.3° 6.0 58.2 -31.8
Model 2 TVAVIVGASVGGFLAVVILVLMVVKCV 6.7 -47.9° 0.0 37.8 -27.3
Model 3 TVAVIVGASVGGFLAVVILVLMVVKCV 6.8 -49.0° 2.8 32.2 -17.0
Model 4 TVAVIVGASVGGFLAVVILVLMVVKCV 7.2 -51.0° 3.3 48.0 -8.8
Model 5 TVAVIVGASVGGFLAVVILVLMVVKCV 7.4 -54.0° 3.6 49.1 -3.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 163, GLY, HA1 A, 160, VAL, O 2.55Å
B, 164, ALA, HA A, 163, GLY, O 2.47Å
B, 167, GLY, HA1 A, 164, ALA, O 3.44Å
A, 163, GLY, HA1 B, 160, VAL, O 2.55Å
A, 164, ALA, HA B, 163, GLY, O 2.47Å
A, 167, GLY, HA1 B, 164, ALA, O 3.44Å