Neuropilin-2

UniProt data

UniProt name: NRP2_HUMAN (O60462)

Gene name: NRP2; Synonyms=VEGF165R2

Organism: Homo sapiens (Human).

Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Subcellular location: Isoform s9: Secreted {ECO:0000269|PubMed:11112349}.

Transmembrane domains:

  1. 865-889, 25 AA, Helical. {ECO:0000255}.

Sequence: 931 AA

10 20 30 40 50 60 MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML 130 140 150 160 170 180 YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQPKLFE GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF LEEPCGWMYD 670 680 690 700 710 720 HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QATGGRGVAL QVVREASQES KLLWVIREDQ GGEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEIAIDDIR ISTDVPLENC MEPISAFAGE NFKVDIPEIH EREGYEDEID DEYEVDWSNS 850 860 870 880 890 900 SSATSGSGAP STDKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR 910 920 930 SCTTLENYNF ELYDGLKHKV KMNHQKCCSE A

CATM prediction

The sequence of NRP2_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          870       880       890
   +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LDAILITIIAMSSLGVLLGATCAGLLLYCTC 6.4 -47.0° 4.8 56.0 -41.3
Model 2 LDAILITIIAMSSLGVLLGATCAGLLLYCTC 7.4 -45.8° 3.6 37.6 -20.1
Model 3 LDAILITIIAMSSLGVLLGATCAGLLLYCTC 6.9 -55.2° 2.4 48.1 -19.5
Model 4 LDAILITIIAMSSLGVLLGATCAGLLLYCTC 7.3 -54.0° 3.6 48.8 -18.1
Model 5 LDAILITIIAMSSLGVLLGATCAGLLLYCTC 7.4 -53.9° 2.9 50.8 -14.5
Prolines* LDPILITIIAMSSLGVLLGATCAGLLLYCTC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 876, GLY, HA1 A, 873, SER, O 3.12Å
B, 877, VAL, HA A, 876, GLY, O 2.50Å
B, 880, GLY, HA1 A, 877, VAL, O 3.10Å
A, 876, GLY, HA1 B, 873, SER, O 3.12Å
A, 877, VAL, HA B, 876, GLY, O 2.50Å
A, 880, GLY, HA1 B, 877, VAL, O 3.10Å