Lymphocyte antigen 75

UniProt data

UniProt name: LY75_HUMAN (O60449)

Gene name: LY75; Synonyms=CD205, CLEC13B

Organism: Homo sapiens (Human).

Function: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 1667-1691, 25 AA, Helical. {ECO:0000255}.

Sequence: 1722 AA

10 20 30 40 50 60 MRTGWATPRR PAGLLMLLFW FFDLAEPSGR AANDPFTIVH GNTGKCIKPV YGWIVADDCD 70 80 90 100 110 120 ETEDKLWKWV SQHRLFHLHS QKCLGLDITK SVNELRMFSC DSSAMLWWKC EHHSLYGAAR 130 140 150 160 170 180 YRLALKDGHG TAISNASDVW KKGGSEESLC DQPYHEIYTR DGNSYGRPCE FPFLIDGTWH 190 200 210 220 230 240 HDCILDEDHS GPWCATTLNY EYDRKWGICL KPENGCEDNW EKNEQFGSCY QFNTQTALSW 250 260 270 280 290 300 KEAYVSCQNQ GADLLSINSA AELTYLKEKE GIAKIFWIGL NQLYSARGWE WSDHKPLNFL 310 320 330 340 350 360 NWDPDRPSAP TIGGSSCARM DAESGLWQSF SCEAQLPYVC RKPLNNTVEL TDVWTYSDTR 370 380 390 400 410 420 CDAGWLPNNG FCYLLVNESN SWDKAHAKCK AFSSDLISIH SLADVEVVVT KLHNEDIKEE 430 440 450 460 470 480 VWIGLKNINI PTLFQWSDGT EVTLTYWDEN EPNVPYNKTP NCVSYLGELG QWKVQSCEEK 490 500 510 520 530 540 LKYVCKRKGE KLNDASSDKM CPPDEGWKRH GETCYKIYED EVPFGTNCNL TITSRFEQEY 550 560 570 580 590 600 LNDLMKKYDK SLRKYFWTGL RDVDSCGEYN WATVGGRRRA VTFSNWNFLE PASPGGCVAM 610 620 630 640 650 660 STGKSVGKWE VKDCRSFKAL SICKKMSGPL GPEEASPKPD DPCPEGWQSF PASLSCYKVF 670 680 690 700 710 720 HAERIVRKRN WEEAERFCQA LGAHLSSFSH VDEIKEFLHF LTDQFSGQHW LWIGLNKRSP 730 740 750 760 770 780 DLQGSWQWSD RTPVSTIIMP NEFQQDYDIR DCAAVKVFHR PWRRGWHFYD DREFIYLRPF 790 800 810 820 830 840 ACDTKLEWVC QIPKGRTPKT PDWYNPDRAG IHGPPLIIEG SEYWFVADLH LNYEEAVLYC 850 860 870 880 890 900 ASNHSFLATI TSFVGLKAIK NKIANISGDG QKWWIRISEW PIDDHFTYSR YPWHRFPVTF 910 920 930 940 950 960 GEECLYMSAK TWLIDLGKPT DCSTKLPFIC EKYNVSSLEK YSPDSAAKVQ CSEQWIPFQN 970 980 990 1000 1010 1020 KCFLKIKPVS LTFSQASDTC HSYGGTLPSV LSQIEQDFIT SLLPDMEATL WIGLRWTAYE 1030 1040 1050 1060 1070 1080 KINKWTDNRE LTYSNFHPLL VSGRLRIPEN FFEEESRYHC ALILNLQKSP FTGTWNFTSC 1090 1100 1110 1120 1130 1140 SERHFVSLCQ KYSEVKSRQT LQNASETVKY LNNLYKIIPK TLTWHSAKRE CLKSNMQLVS 1150 1160 1170 1180 1190 1200 ITDPYQQAFL SVQALLHNSS LWIGLFSQDD ELNFGWSDGK RLHFSRWAET NGQLEDCVVL 1210 1220 1230 1240 1250 1260 DTDGFWKTVD CNDNQPGAIC YYSGNETEKE VKPVDSVKCP SPVLNTPWIP FQNCCYNFII 1270 1280 1290 1300 1310 1320 TKNRHMATTQ DEVHTKCQKL NPKSHILSIR DEKENNFVLE QLLYFNYMAS WVMLGITYRN 1330 1340 1350 1360 1370 1380 KSLMWFDKTP LSYTHWRAGR PTIKNEKFLA GLSTDGFWDI QTFKVIEEAV YFHQHSILAC 1390 1400 1410 1420 1430 1440 KIEMVDYKEE YNTTLPQFMP YEDGIYSVIQ KKVTWYEALN MCSQSGGHLA SVHNQNGQLF 1450 1460 1470 1480 1490 1500 LEDIVKRDGF PLWVGLSSHD GSESSFEWSD GSTFDYIPWK GQTSPGNCVL LDPKGTWKHE 1510 1520 1530 1540 1550 1560 KCNSVKDGAI CYKPTKSKKL SRLTYSSRCP AAKENGSRWI QYKGHCYKSD QALHSFSEAK 1570 1580 1590 1600 1610 1620 KLCSKHDHSA TIVSIKDEDE NKFVSRLMRE NNNITMRVWL GLSQHSVDQS WSWLDGSEVT 1630 1640 1650 1660 1670 1680 FVKWENKSKS GVGRCSMLIA SNETWKKVEC EHGFGRVVCK VPLGPDYTAI AIIVATLSIL 1690 1700 1710 1720 VLMGGLIWFL FQRHRLHLAG FSSVRYAQGV NEDEIMLPSF HD

CATM prediction

The sequence of LY75_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        1670      1680      1690 
 +    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 GADYTAIAIIVATLSILVLMGGLIWFLFQRH 6.9 -55.1° 0.9 50.0 -24.6
Prolines* GPDYTAIAIIVATLSILVLMGGLIWFLFQRH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1684, GLY, HA1 A, 1681, VAL, O 2.91Å
B, 1685, GLY, HA2 A, 1684, GLY, O 3.14Å
A, 1684, GLY, HA1 B, 1681, VAL, O 2.91Å
A, 1685, GLY, HA2 B, 1684, GLY, O 3.14Å