Endothelin-converting enzyme 2

UniProt data

UniProt name: ECE2_HUMAN (O60344)

Gene name: ECE2; Synonyms=KIAA0604; ORFNames=UNQ403/PRO740

Organism: Homo sapiens (Human).

Function: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. {ECO:0000269|PubMed:12560336}.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 179-199, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 883 AA

10 20 30 40 50 60 MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED 70 80 90 100 110 120 RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP 130 140 150 160 170 180 SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VGFQKGTRQL LGSRTQLELV 190 200 210 220 230 240 LAGASLLLAA LLLGCLVALG VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ 250 260 270 280 290 300 FSCGGWIRRN PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL 310 320 330 340 350 360 QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF FTVYISADSK 370 380 390 400 410 420 SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME ELGMLLGGRP TSTREQMQQV 430 440 450 460 470 480 LELEIQLANI TVPQDQRRDE EKIYHKMSIS ELQALAPSMD WLEFLSFLLS PLELSDSEPV 490 500 510 520 530 540 VVYGMDYLQQ VSELINRTEP SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS 550 560 570 580 590 600 CVPRWQTCIS NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE 610 620 630 640 650 660 KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL YNFSAKVMAD 670 680 690 700 710 720 QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF YARNHPKALN FGGIGVVMGH 730 740 750 760 770 780 ELTHAFDDQG REYDKEGNLR PWWQNESLAA FRNHTACMEE QYNQYQVNGE RLNGRQTLGE 790 800 810 820 830 840 NIADNGGLKA AYNAYKAWLR KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL 850 860 870 880 VTDPHSPARF RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVW

CATM prediction

The sequence of ECE2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      180       190       200
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 QLELVLAGASLLLAALLLGCLVALGVQ 6.8 -45.9° 2.7 46.8 -36.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 191, LEU, HA A, 190, ALA, O 2.84Å
B, 194, GLY, HA1 A, 191, LEU, O 2.79Å
B, 195, CYS, HA A, 194, GLY, O 3.38Å
A, 191, LEU, HA B, 190, ALA, O 2.84Å
A, 194, GLY, HA1 B, 191, LEU, O 2.79Å
A, 195, CYS, HA B, 194, GLY, O 3.38Å