Dynamin-like 120 kDa protein, mitochondrial

UniProt data

UniProt name: OPA1_HUMAN (O60313)

Gene name: OPA1; Synonyms=KIAA0567

Organism: Homo sapiens (Human).

Function: Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion. {ECO:0000269|PubMed:20038677}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:11017079, ECO:0000269|PubMed:16778770}; Single-pass membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P58281}.

Transmembrane domains:

  1. 97-113, 17 AA, Helical. {ECO:0000255}.

Sequence: 960 AA

10 20 30 40 50 60 MWRLRRAAVA CEVCQSLVKH SSGIKGSLPL QKLHLVSRSI YHSHHPTLKL QRPQLRTSFQ 70 80 90 100 110 120 QFSSLTNLPL RKLKFSPIKY GYQPRRNFWP ARLATRLLKL RYLILGSAVG GGYTAKKTFD 130 140 150 160 170 180 QWKDMIPDLS EYKWIVPDIV WEIDEYIDFE KIRKALPSSE DLVKLAPDFD KIVESLSLLK 190 200 210 220 230 240 DFFTSGSPEE TAFRATDRGS ESDKHFRKVS DKEKIDQLQE ELLHTQLKYQ RILERLEKEN 250 260 270 280 290 300 KELRKLVLQK DDKGIHHRKL KKSLIDMYSE VLDVLSDYDA SYNTQDHLPR VVVVGDQSAG 310 320 330 340 350 360 KTSVLEMIAQ ARIFPRGSGE MMTRSPVKVT LSEGPHHVAL FKDSSREFDL TKEEDLAALR 370 380 390 400 410 420 HEIELRMRKN VKEGCTVSPE TISLNVKGPG LQRMVLVDLP GVINTVTSGM APDTKETIFS 430 440 450 460 470 480 ISKAYMQNPN AIILCIQDGS VDAERSIVTD LVSQMDPHGR RTIFVLTKVD LAEKNVASPS 490 500 510 520 530 540 RIQQIIEGKL FPMKALGYFA VVTGKGNSSE SIEAIREYEE EFFQNSKLLK TSMLKAHQVT 550 560 570 580 590 600 TRNLSLAVSD CFWKMVRESV EQQADSFKAT RFNLETEWKN NYPRLRELDR NELFEKAKNE 610 620 630 640 650 660 ILDEVISLSQ VTPKHWEEIL QQSLWERVST HVIENIYLPA AQTMNSGTFN TTVDIKLKQW 670 680 690 700 710 720 TDKQLPNKAV EVAWETLQEE FSRFMTEPKG KEHDDIFDKL KEAVKEESIK RHKWNDFAED 730 740 750 760 770 780 SLRVIQHNAL EDRSISDKQQ WDAAIYFMEE ALQARLKDTE NAIENMVGPD WKKRWLYWKN 790 800 810 820 830 840 RTQEQCVHNE TKNELEKMLK CNEEHPAYLA SDEITTVRKN LESRGVEVDP SLIKDTWHQV 850 860 870 880 890 900 YRRHFLKTAL NHCNLCRRGF YYYQRHFVDS ELECNDVVLF WRIQRMLAIT ANTLRQQLTN 910 920 930 940 950 TEVRRLEKNV KEVLEDFAED GEKKIKLLTG KRVQLAEDLK KVREIQEKLD AFIEALHQEK

CATM prediction

The sequence of OPA1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        100       110    
 +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ATRLLKLRYLILGSAVGGGYTAK 6.6 -40.0° 4.0 38.2 -26.7
Model 2 ATRLLKLRYLILGSAVGGGYTAK 7.3 -35.8° 3.6 36.2 -9.8
Model 3 ATRLLKLRYLILGSAVGGGYTAK 7.1 -43.0° 0.0 34.0 -1.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 106, GLY, HA1 A, 103, LEU, O 3.37Å
B, 107, SER, HA A, 106, GLY, O 2.62Å
B, 110, GLY, HA1 A, 107, SER, O 2.72Å
B, 111, GLY, HA2 A, 110, GLY, O 3.37Å
A, 106, GLY, HA1 B, 103, LEU, O 3.37Å
A, 107, SER, HA B, 106, GLY, O 2.62Å
A, 110, GLY, HA1 B, 107, SER, O 2.72Å
A, 111, GLY, HA2 B, 110, GLY, O 3.37Å