UniProt data
UniProt name: PCDH7_HUMAN (O60245)
Gene name: PCDH7; Synonyms=BHPCDH
Organism: Homo sapiens (Human).
Function:
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 880-900, 21 AA, Helical. {ECO:0000255}.
Sequence: 1069 AA
10 20 30 40 50 60
MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN VASDLGIVTG
70 80 90 100 110 120
SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ MIFDENECFL DFEVSVIGPS
130 140 150 160 170 180
QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL TVEENRPVGT LYLLPTATDR DFGRNGIERY
190 200 210 220 230 240
ELLQEPGGGG SGGESRRAGA ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR
250 260 270 280 290 300
SSVFELQVAD TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD
310 320 330 340 350 360
VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA TESVRRLLRL
370 380 390 400 410 420
DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT VVLNIKDEND NVPSIEIRKI
430 440 450 460 470 480
GRIPLKDGVA NVAEDVLVDT PIALVQVSDR DQGENGVVTC TVVGDVPFQL KPASDTEGDQ
490 500 510 520 530 540
NKKKYFLHTS TPLDYEATRE FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV
550 560 570 580 590 600
EVYFPENNIP GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE
610 620 630 640 650 660
QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE NLQPNSPVGM
670 680 690 700 710 720
VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF DREHQTTYTF RVKAVDGGDP
730 740 750 760 770 780
PRSATATVSL FVMDENDNAP TVTLPKNISY TLLPPSSNVR TVVATVLATD SDDGINADLN
790 800 810 820 830 840
YSIVGGNPFK LFEIDPTSGV VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN
850 860 870 880 890 900
ESVSNATAID SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM
910 920 930 940 950 960
ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS IVTVEASKPN
970 980 990 1000 1010 1020
GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS PLPTVQLHPQ SPTAGKKHQA
1030 1040 1050 1060
VQDLPPANTF VGAGDNISIG SDHCSEYSCQ TNNKYSKQMR LHPYITVFG
CATM prediction
The sequence of PCDH7_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 880 890 900 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RLSIVIGVVAGIMTVILIILIVVMARY | 6.6 | -47.9° | 0.8 | 54.1 | -27.7 |
| Model 2 | RLSIVIGVVAGIMTVILIILIVVMARY | 7.3 | -54.0° | 3.6 | 49.0 | -4.1 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 883, GLY, HA1 | A, 880, ILE, O | 2.90Å |
| B, 884, VAL, HA | A, 883, GLY, O | 2.76Å |
| A, 883, GLY, HA1 | B, 880, ILE, O | 2.90Å |
| A, 884, VAL, HA | B, 883, GLY, O | 2.76Å |
