TYRO protein tyrosine kinase-binding protein

UniProt data

UniProt name: TYOBP_HUMAN (O43914)

Gene name: TYROBP; Synonyms=DAP12, KARAP

Organism: Homo sapiens (Human).

Function: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 41-61, 21 AA, Helical. {ECO:0000255}.

Sequence: 113 AA

10 20 30 40 50 60 MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD LVLTVLIALA 70 80 90 100 110 VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD VYSDLNTQRP YYK

CATM prediction

The sequence of TYOBP_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    40        50        60   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 VSAGVLAGIVMGDLVLTVLIALAVYFL 6.5 -38.9° 3.9 53.8 -35.4
Model 2 VSAGVLAGIVMGDLVLTVLIALAVYFL 6.3 -53.6° 3.0 62.2 -25.0
Model 3 VSAGVLAGIVMGDLVLTVLIALAVYFL 7.2 -55.2° 0.3 45.2 -12.8
Model 4 VSAGVLAGIVMGDLVLTVLIALAVYFL 7.1 -40.0° 2.7 34.0 -7.0
Prolines* VSPGVLAGIVMGDLVLTVLIALAVYFL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 42, VAL, HA A, 41, GLY, O 2.55Å
B, 45, GLY, HA1 A, 42, VAL, O 2.89Å
B, 46, ILE, HA A, 45, GLY, O 3.31Å
A, 42, VAL, HA B, 41, GLY, O 2.55Å
A, 45, GLY, HA1 B, 42, VAL, O 2.89Å
A, 46, ILE, HA B, 45, GLY, O 3.31Å