UniProt data
UniProt name: ITM2A_HUMAN (O43736)
Gene name: ITM2A; ORFNames=UNQ603/PRO1189
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Transmembrane domains:
- 54-74, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 263 AA
10 20 30 40 50 60
MVKIAFNTPT AVQKEEARQD VEALLSRTVR TQILTGKELR VATQEKEGSS GRCMLTLLGL
70 80 90 100 110 120
SFILAGLIVG GACIYKYFMP KSTIYRGEMC FFDSEDPANS LRGGEPNFLP VTEEADIRED
130 140 150 160 170 180
DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT AYLDLLLGNC YLMPLNTSIV MPPKNLVELF
190 200 210 220 230 240
GKLASGRYLP QTYVVREDLV AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA
250 260
IDKCWKIRHF PNEFIVETKI CQE
CATM prediction
The sequence of ITM2A_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 60 70 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GRCMLTLLGLSFILAGLIVGGACIYKY | 7.0 | -46.0° | 2.7 | 47.1 | -20.6 |
| Model 2 | GRCMLTLLGLSFILAGLIVGGACIYKY | 6.9 | -55.0° | 1.5 | 45.1 | -14.2 |
| Model 3 | GRCMLTLLGLSFILAGLIVGGACIYKY | 7.4 | -41.0° | 3.5 | 38.1 | -7.0 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 63, ILE, HA | A, 62, PHE, O | 3.03Å |
| B, 66, GLY, HA1 | A, 63, ILE, O | 2.92Å |
| B, 67, LEU, HA | A, 66, GLY, O | 3.39Å |
| A, 63, ILE, HA | B, 62, PHE, O | 3.03Å |
| A, 66, GLY, HA1 | B, 63, ILE, O | 2.92Å |
| A, 67, LEU, HA | B, 66, GLY, O | 3.39Å |
