Sialic acid-binding Ig-like lectin 6

UniProt data

UniProt name: SIGL6_HUMAN (O43699)

Gene name: SIGLEC6; Synonyms=CD33L, CD33L1, OBBP1

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 348-368, 21 AA, Helical. {ECO:0000255}.

Sequence: 453 AA

10 20 30 40 50 60 MQGAQEASAS EMLPLLLPLL WAGALAQERR FQLEGPESLT VQEGLCVLVP CRLPTTLPAS 70 80 90 100 110 120 YYGYGYWFLE GADVPVATND PDEEVQEETR GRFHLLWDPR RKNCSLSIRD ARRRDNAAYF 130 140 150 160 170 180 FRLKSKWMKY GYTSSKLSVR VMALTHRPNI SIPGTLESGH PSNLTCSVPW VCEQGTPPIF 190 200 210 220 230 240 SWMSAAPTSL GPRTTQSSVL TITPRPQDHS TNLTCQVTFP GAGVTMERTI QLNVSYAPQK 250 260 270 280 290 300 VAISIFQGNS AAFKILQNTS SLPVLEGQAL RLLCDADGNP PAHLSWFQGF PALNATPISN 310 320 330 340 350 360 TGVLELPQVG SAEEGDFTCR AQHPLGSLQI SLSLFVHWKP EGRAGGVLGA VWGASITTLV 370 380 390 400 410 420 FLCVCFIFRV KTRRKKAAQP VQNTDDVNPV MVSGSRGHQH QFQTGIVSDH PAEAGPISED 430 440 450 EQELHYAVLH FHKVQPQEPK VTDTEYSEIK IHK

CATM prediction

The sequence of SIGL6_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       350       360       37
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 GGVLGAVWGASITTLVFLCVCFIFRVK 7.1 -48.0° 4.3 34.8 -30.0
Model 2 GGVLGAVWGASITTLVFLCVCFIFRVK 7.2 -24.0° 3.3 49.0 -24.1
Model 3 GGVLGAVWGASITTLVFLCVCFIFRVK 6.4 -55.0° 5.9 47.1 -14.9
Model 4 GGVLGAVWGASITTLVFLCVCFIFRVK 6.5 -31.0° 6.0 55.0 -9.2
Model 5 GGVLGAVWGASITTLVFLCVCFIFRVK 6.6 +35.0° 4.5 74.0 -0.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 350, ALA, HA A, 349, GLY, O 2.89Å
B, 353, GLY, HA1 A, 350, ALA, O 2.91Å
B, 354, ALA, HA A, 357, THR, OG1 2.56Å
A, 350, ALA, HA B, 349, GLY, O 2.89Å
A, 353, GLY, HA1 B, 350, ALA, O 2.91Å
A, 354, ALA, HA B, 357, THR, OG1 2.56Å