NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

UniProt data

UniProt name: NDUC1_HUMAN (O43677)

Gene name: NDUFC1

Organism: Homo sapiens (Human).

Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Transmembrane domains:

  1. 41-59, 19 AA, Helical. {ECO:0000255}.

Sequence: 76 AA

10 20 30 40 50 60 MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT TVFLWIYLIK 70 QHNEDILEYK RRNGLE

CATM prediction

The sequence of NDUC1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    40        50        60 
  |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 KADWLKVGFTLGTTVFLWIYLIKQH 6.8 -43.0° 2.4 44.1 -20.7
Model 2 KADWLKVGFTLGTTVFLWIYLIKQH 7.0 -55.1° 2.4 48.1 -4.4
Prolines* KPDWLKVGFTLGTTVFLWIYLIKQH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 42, LEU, HA A, 41, TRP, O 2.88Å
B, 45, GLY, HA1 A, 42, LEU, O 2.78Å
B, 46, PHE, HA A, 45, GLY, O 3.16Å
A, 42, LEU, HA B, 41, TRP, O 2.88Å
A, 45, GLY, HA1 B, 42, LEU, O 2.78Å
A, 46, PHE, HA B, 45, GLY, O 3.16Å