NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

UniProt data

UniProt name: NDUB3_HUMAN (O43676)

Gene name: NDUFB3

Organism: Homo sapiens (Human).

Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Transmembrane domains:

  1. 66-88, 23 AA, Helical. {ECO:0000255}.

Sequence: 98 AA

10 20 30 40 50 60 MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA WRYMGGFAKS 70 80 90 VSFSDVFFKG FKWGFAAFVV AVGAEYYLES LNKDKKHH

CATM prediction

The sequence of NDUB3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         70        80        90
  +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 FSDVFFKGFKWGFAAFVVAVGAEYYLESL 7.1 -49.2° 1.8 45.1 -25.3
Model 2 FSDVFFKGFKWGFAAFVVAVGAEYYLESL 7.2 -37.1° 2.3 35.9 -15.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 67, PHE, HA A, 66, VAL, O 3.22Å
B, 70, GLY, HA1 A, 67, PHE, O 2.88Å
B, 71, PHE, HA A, 70, GLY, O 3.25Å
A, 67, PHE, HA B, 66, VAL, O 3.22Å
A, 70, GLY, HA1 B, 67, PHE, O 2.88Å
A, 71, PHE, HA B, 70, GLY, O 3.25Å