NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

UniProt data

UniProt name: NDUB5_HUMAN (O43674)

Gene name: NDUFB5

Organism: Homo sapiens (Human).

Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Transmembrane domains:

  1. 73-93, 21 AA, Helical. {ECO:0000255}.

Sequence: 189 AA

10 20 30 40 50 60 MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH GKRLFVIRPS 70 80 90 100 110 120 RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE IPEGYVPEHW EYYKHPISRW 130 140 150 160 170 180 IARNFYDSPE KIYERTMAVL QIEAEKAELR VKELEVRKLM HVRGDGPWYY YETIDKELID HSPKATPDN

CATM prediction

The sequence of NDUB5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  70        80        90     
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 LLRFYIALTGIAVAIFITLVNVFIGQA 7.2 -46.6° 1.3 45.1 -31.2
Prolines* LLRFYIALTGIPVAIFITLVNVFIGQA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 79, GLY, HA1 A, 76, ALA, O 3.17Å
B, 80, ILE, HA A, 79, GLY, O 3.39Å
A, 79, GLY, HA1 B, 76, ALA, O 3.17Å
A, 80, ILE, HA B, 79, GLY, O 3.39Å