UniProt data
UniProt name: CAH12_HUMAN (O43570)
Gene name: CA12
Organism: Homo sapiens (Human).
Function: Reversible hydration of carbon dioxide.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 302-322, 21 AA, Helical. {ECO:0000255}.
Sequence: 354 AA
10 20 30 40 50 60
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL
70 80 90 100 110 120
HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL
130 140 150 160 170 180
HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN
190 200 210 220 230 240
PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR
250 260 270 280 290 300
NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL
310 320 330 340 350
SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA
CATM prediction
The sequence of CAH12_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 300 310 320 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GLSLGIILSLALAGILGICIVVVVSIW | 7.1 | -47.9° | 5.1 | 38.9 | -20.1 |
| Model 2 | GLSLGIILSLALAGILGICIVVVVSIW | 6.6 | -47.0° | 4.8 | 56.0 | -13.1 |
| Model 3 | GLSLGIILSLALAGILGICIVVVVSIW | 7.4 | -48.1° | 0.5 | 46.9 | -8.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 312, GLY, HA2 | A, 311, ALA, O | 3.04Å |
| B, 315, GLY, HA1 | A, 312, GLY, O | 3.43Å |
| A, 312, GLY, HA2 | B, 311, ALA, O | 3.04Å |
| A, 315, GLY, HA1 | B, 312, GLY, O | 3.43Å |
