Tumor necrosis factor ligand superfamily member 14

UniProt data

UniProt name: TNF14_HUMAN (O43557)

Gene name: TNFSF14; Synonyms=HVEML, LIGHT; ORFNames=UNQ391/PRO726

Organism: Homo sapiens (Human).

Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Subcellular location: Isoform 2: Cytoplasm.

Transmembrane domains:

  1. 38-58, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 240 AA

10 20 30 40 50 60 MEESVVRPSV FVVDGQTDIP FTRLGRSHRR QSCSVARVGL GLLLLLMGAG LAVQGWFLLQ 70 80 90 100 110 120 LHWRLGEMVT RLPDGPAGSW EQLIQERRSH EVNPAAHLTG ANSSLTGSGG PLLWETQLGL 130 140 150 160 170 180 AFLRGLSYHD GALVVTKAGY YYIYSKVQLG GVGCPLGLAS TITHGLYKRT PRYPEELELL 190 200 210 220 230 VSQQSPCGRA TSSSRVWWDS SFLGGVVHLE AGEKVVVRVL DERLVRLRDG TRSYFGAFMV

CATM prediction

The sequence of TNF14_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       40        50        60
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 VARVGLGLLLLLMGAGLAVQGWFLLQL 7.1 -42.0° 1.4 44.8 -46.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 45, LEU, HA A, 44, LEU, O 3.28Å
B, 48, GLY, HA1 A, 45, LEU, O 3.06Å
B, 49, ALA, HA A, 48, GLY, O 3.31Å
A, 45, LEU, HA B, 44, LEU, O 3.28Å
A, 48, GLY, HA1 B, 45, LEU, O 3.06Å
A, 49, ALA, HA B, 48, GLY, O 3.31Å