Tumor necrosis factor ligand superfamily member 12

UniProt data

UniProt name: TNF12_HUMAN (O43508)

Gene name: TNFSF12; Synonyms=APO3L, DR3LG; ORFNames=UNQ181/PRO207

Organism: Homo sapiens (Human).

Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.

Subcellular location: Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 22-42, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 249 AA

10 20 30 40 50 60 MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL 70 80 90 100 110 120 VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD 130 140 150 160 170 180 GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD 190 200 210 220 230 240 LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL TYFGLFQVH

CATM prediction

The sequence of TNF12_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   20        30        40    
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 ALLVALALGLGLALACLGLLLAVVSLG 7.1 -50.2° 2.8 47.2 -24.0
Model 2 ALLVALALGLGLALACLGLLLAVVSLG 7.2 -43.0° 3.4 50.0 -7.5
Prolines* ALLVPLALGLGLALACLGLLLAVVSLG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 24, LEU, HA A, 23, ALA, O 3.04Å
B, 27, GLY, HA1 A, 24, LEU, O 2.89Å
A, 24, LEU, HA B, 23, ALA, O 3.04Å
A, 27, GLY, HA1 B, 24, LEU, O 2.89Å