UniProt data
UniProt name: SPIT2_HUMAN (O43291)
Gene name: SPINT2; Synonyms=HAI2, KOP
Organism: Homo sapiens (Human).
Function: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 198-218, 21 AA, Helical. {ECO:0000255}.
Sequence: 252 AA
10 20 30 40 50 60
MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS MPRWWYNVTD
70 80 90 100 110 120
GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA TSRNAADSSV PSAPRRQDSE
130 140 150 160 170 180
DHSSDMFNYE EYCTANAVTG PCRASFPRWY FDVERNSCNN FIYGGCRGNK NSYRSEEACM
190 200 210 220 230 240
LRCFRQQENP PLPLGSKVVV LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD
250
DKEQLVKNTY VL
CATM prediction
The sequence of SPIT2_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 200 210 22 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GSKVVVLAGLFVMVLILFLGASMVYLI | 7.4 | -50.3° | 2.8 | 47.0 | -14.3 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 211, LEU, HA | A, 210, ILE, O | 3.44Å |
| B, 214, GLY, HA1 | A, 211, LEU, O | 3.39Å |
| A, 211, LEU, HA | B, 210, ILE, O | 3.44Å |
| A, 214, GLY, HA1 | B, 211, LEU, O | 3.39Å |