Disintegrin and metalloproteinase domain-containing protein 12

UniProt data

UniProt name: ADA12_HUMAN (O43184)

Gene name: ADAM12; Synonyms=MLTN; ORFNames=UNQ346/PRO545

Organism: Homo sapiens (Human).

Function: Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). {ECO:0000250}.

Subcellular location: Isoform 4: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 709-729, 21 AA, Helical. {ECO:0000255}.

Sequence: 909 AA

10 20 30 40 50 60 MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG DLWIPVKSFD 70 80 90 100 110 120 SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY 130 140 150 160 170 180 YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG 190 200 210 220 230 240 SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR 250 260 270 280 290 300 LIEIANHVDK FYRPLNIRIV LVGVEVWNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH 310 320 330 340 350 360 DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN PLGAAVTLAH ELGHNFGMNH 370 380 390 400 410 420 DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE 430 440 450 460 470 480 SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT 490 500 510 520 530 540 ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG 550 560 570 580 590 600 AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS 610 620 630 640 650 660 IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC 670 680 690 700 710 720 AMQCHGRGVC NNRKNCHCEA HWAPPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL 730 740 750 760 770 780 LAAGFVVYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP 790 800 810 820 830 840 DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP 850 860 870 880 890 900 ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP RSTHTAYIK

CATM prediction

The sequence of ADA12_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      710       720       730
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 NQGLTIGILVTILCLLAAGFVVYLKRK 6.9 -45.0° 5.5 45.1 -10.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 712, GLY, HA1 A, 709, LEU, O 3.35Å
B, 716, THR, HG1 A, 716, THR, OG1 2.47Å
A, 712, GLY, HA1 B, 709, LEU, O 3.35Å
A, 713, ILE, HA B, 716, THR, OG1 3.42Å