Cytochrome b5 type B

UniProt data

UniProt name: CYB5B_HUMAN (O43169)

Gene name: CYB5B; Synonyms=CYB5M, OMB5

Organism: Homo sapiens (Human).

Function: Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. {ECO:0000250}.

Subcellular location: Mitochondrion outer membrane {ECO:0000250}.

Transmembrane domains:

  1. 119-136, 18 AA, Helical. {ECO:0000255}.

Sequence: 146 AA

10 20 30 40 50 60 MATAEASGSD GKGQEVETSV TYYRLEEVAK RNSLKELWLV IHGRVYDVTR FLNEHPGGEE 70 80 90 100 110 120 VLLEQAGVDA SESFEDVGHS SDAREMLKQY YIGDIHPSDL KPESGSKDPS KNDTCKSCWA 130 140 YWILPIIGAV LLGFLYRYYT SESKSS

CATM prediction

The sequence of CYB5B_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      120       130       
    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 KSCWAYWILAIIGAVLLGFLYRYY 7.1 -53.8° 2.5 33.2 -13.0
Model 2 KSCWAYWILAIIGAVLLGFLYRYY 6.7 -46.2° 2.7 46.9 -7.5
Prolines* KSCWAYWILPIIGAVLLGFLYRYY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 125, ALA, HA A, 124, LEU, O 3.39Å
B, 128, GLY, HA1 A, 125, ALA, O 3.15Å
B, 136, TYR, HH A, 136, TYR, OH 2.02Å
A, 125, ALA, HA B, 124, LEU, O 3.39Å
A, 128, GLY, HA1 B, 125, ALA, O 3.15Å