Tapasin

UniProt data

UniProt name: TPSN_HUMAN (O15533)

Gene name: TAPBP; Synonyms=NGS17, TAPA

Organism: Homo sapiens (Human).

Function: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). {ECO:0000269|PubMed:10636848}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 415-435, 21 AA, Helical. {ECO:0000255}.

Sequence: 448 AA

10 20 30 40 50 60 MKSLSLLLAV ALGLATAVSA GPAVIECWFV EDASGKGLAK RPGALLLRQG PGEPPPRPDL 70 80 90 100 110 120 DPELYLSVHD PAGALQAAFR RYPRGAPAPH CEMSRFVPLP ASAKWASGLT PAQNCPRALD 130 140 150 160 170 180 GAWLMVSISS PVLSLSSLLR PQPEPQQEPV LITMATVVLT VLTHTPAPRV RLGQDALLDL 190 200 210 220 230 240 SFAYMPPTSE AASSLAPGPP PFGLEWRRQH LGKGHLLLAA TPGLNGQMPA AQEGAVAFAA 250 260 270 280 290 300 WDDDEPWGPW TGNGTFWLPR VQPFQEGTYL ATIHLPYLQG QVTLELAVYK PPKVSLMPAT 310 320 330 340 350 360 LARAAPGEAP PELLCLVSHF YPSGGLEVEW ELRGGPGGRS QKAEGQRWLS ALRHHSDGSV 370 380 390 400 410 420 SLSGHLQPPP VTTEQHGARY ACRIHHPSLP ASGRSAEVTL EVAGLSGPSL EDSVGLFLSA 430 440 FLLLGLFKAL GWAAVYLSTC KDSKKKAE

CATM prediction

The sequence of TPSN_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          420       430      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 DSVGLFLSAFLLLGLFKALGWAAVYLS 7.2 -40.0° 1.9 44.0 -17.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 422, LEU, HA A, 421, PHE, O 3.34Å
B, 425, GLY, HA1 A, 422, LEU, O 3.22Å
B, 426, LEU, HA A, 425, GLY, O 3.42Å
A, 422, LEU, HA B, 421, PHE, O 3.34Å
A, 425, GLY, HA1 B, 422, LEU, O 3.22Å
A, 426, LEU, HA B, 425, GLY, O 3.42Å