UniProt data
UniProt name: NCAM2_HUMAN (O15394)
Gene name: NCAM2; Synonyms=NCAM21
Organism: Homo sapiens (Human).
Function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 698-718, 21 AA, Helical. {ECO:0000255}.
Sequence: 837 AA
10 20 30 40 50 60
MSLLLSFYLL GLLVSSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES IDWYNPQGEK
70 80 90 100 110 120
IISTQRVVVQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG QTQEATVVLE IYQKLTFREV
130 140 150 160 170 180
VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY HNEEVTTISD NRFAMLANNN LQILNINKSD
190 200 210 220 230 240
EGIYRCEGRV EARGEIDFRD IIVIVNVPPA ISMPQKSFNA TAERGEEMTF SCRASGSPEP
250 260 270 280 290 300
AISWFRNGKL IEENEKYILK GSNTELTVRN IINSDGGPYV CRATNKAGED EKQAFLQVFV
310 320 330 340 350 360
QPHIIQLKNE TTYENGQVTL VCDAEGEPIP EITWKRAVDG FTFTEGDKSL DGRIEVKGQH
370 380 390 400 410 420
GSSSLHIKDV KLSDSGRYDC EAASRIGGHQ KSMYLDIEYA PKFISNQTIY YSWEGNPINI
430 440 450 460 470 480
SCDVKSNPPA SIHWRRDKLV LPAKNTTNLK TYSTGRKMIL EIAPTSDNDF GRYNCTATNH
490 500 510 520 530 540
IGTRFQEYIL ALADVPSSPY GVKIIELSQT TAKVSFNKPD SHGGVPIHHY QVDVKEVASE
550 560 570 580 590 600
IWKIVRSHGV QTMVVLNNLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH
610 620 630 640 650 660
GQPSSGKSFK LSITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH IILEHLQWTM
670 680 690 700 710 720
GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG LGAVIGLGVA ALLLILVVTD
730 740 750 760 770 780
VSCFFIRQCG LLMCITRRMC GKKSGSSGKS KELEEGKAAY LKDGSKEPIV EMRTEDERVT
790 800 810 820 830
NHEDGSPVNE PNETTPLTEP EKLPLKEEDG KEALNPETIE IKVSNDIIQS KEDDSKA
CATM prediction
The sequence of NCAM2_HUMAN returned 6 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 700 710 72 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | LFNGLGLGAVIGLGVAALLLILVVTDV | 6.6 | -28.0° | 3.2 | 48.0 | -41.9 |
| Model 2 | LFNGLGLGAVIGLGVAALLLILVVTDV | 6.3 | -40.9° | 0.0 | 58.8 | -35.7 |
| Model 3 | LFNGLGLGAVIGLGVAALLLILVVTDV | 6.5 | -38.9° | 6.0 | 45.1 | -26.0 |
| Model 4 | LFNGLGLGAVIGLGVAALLLILVVTDV | 6.6 | -43.1° | 3.5 | 50.0 | -20.6 |
| Model 5 | LFNGLGLGAVIGLGVAALLLILVVTDV | 6.4 | -54.7° | 5.0 | 52.6 | -12.7 |
| Model 6 | LFNGLGLGAVIGLGVAALLLILVVTDV | 6.9 | -55.1° | 5.0 | 53.0 | -10.6 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 699, LEU, HA | A, 698, GLY, O | 2.46Å |
| B, 702, GLY, HA1 | A, 699, LEU, O | 2.83Å |
| B, 703, ALA, HA | A, 702, GLY, O | 2.99Å |
| A, 699, LEU, HA | B, 698, GLY, O | 2.46Å |
| A, 702, GLY, HA1 | B, 699, LEU, O | 2.83Å |
| A, 703, ALA, HA | B, 702, GLY, O | 2.99Å |
