Sialic acid-binding Ig-like lectin 5

UniProt data

UniProt name: SIGL5_HUMAN (O15389)

Gene name: SIGLEC5; Synonyms=CD33L2, OBBP2

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 442-462, 21 AA, Helical. {ECO:0000255}.

Sequence: 551 AA

10 20 30 40 50 60 MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW 70 80 90 100 110 120 FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV 130 140 150 160 170 180 ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW 190 200 210 220 230 240 TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQMKRQGA QVTTERTVQL NVSYAPQTIT 250 260 270 280 290 300 IFRNGIALEI LQNTSYLPVL EGQALRLLCD APSNPPAHLS WFQGSPALNA TPISNTGILE 310 320 330 340 350 360 LRRVRSAEEG GFTCRAQHPL GFLQIFLNLS VYSLPQLLGP SCSWEAEGLH CRCSFRARPA 370 380 390 400 410 420 PSLCWRLEEK PLEGNSSQGS FKVNSSSAGP WANSSLILHG GLSSDLKVSC KAWNIYGSQS 430 440 450 460 470 480 GSVLLLQGRS NLGTGVVPAA LGGAGVMALL CICLCLIFFL IVKARRKQAA GRPEKMDDED 490 500 510 520 530 540 PIMGTITSGS RKKPWPDSPG DQASPPGDAP PLEEQKELHY ASLSFSEMKS REPKDQEAPS 550 TTEYSEIKTS K

CATM prediction

The sequence of SIGL5_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   440       450       460   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 AALGGAGVMALLCICLCLIFFLIVKAR 6.6 -41.0° 3.5 38.0 -18.3
Model 2 AALGGAGVMALLCICLCLIFFLIVKAR 6.9 -55.0° 4.2 38.0 -2.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 444, ALA, HA A, 443, GLY, O 3.28Å
A, 444, ALA, HA B, 443, GLY, O 3.28Å