UniProt data
UniProt name: NDUA1_HUMAN (O15239)
Gene name: NDUFA1
Organism: Homo sapiens (Human).
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Transmembrane domains:
- 1-21, 21 AA, Helical. {ECO:0000255}.
Sequence: 70 AA
CATM prediction
The sequence of NDUA1_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 10 20 + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | MWFEILAGLSVMGVCLLIAGLATA | 7.1 | -50.4° | 2.9 | 47.0 | -30.1 |
| Model 2 | MWFEILAGLSVMGVCLLIAGLATA | 7.3 | -40.1° | 1.9 | 44.0 | -15.3 |
| Prolines* | MWFEILPGLSVMGVCLLIPGLATA |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 5, ILE, HA | A, 4, GLU, O | 3.04Å |
| B, 8, GLY, HA1 | A, 5, ILE, O | 2.91Å |
| A, 1, MET, HA | B, 4, GLU, OE1 | 2.08Å |
| A, 1, MET, HA | B, 4, GLU, OE2 | 3.27Å |
| A, 5, ILE, HA | B, 4, GLU, O | 3.04Å |
| A, 8, GLY, HA1 | B, 5, ILE, O | 2.91Å |
