Ephrin type-B receptor 6

UniProt data

UniProt name: EPHB6_HUMAN (O15197)

Gene name: EPHB6

Organism: Homo sapiens (Human).

Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}.

Subcellular location: Isoform 3: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 595-615, 21 AA, Helical. {ECO:0000255}.

Sequence: 1021 AA

10 20 30 40 50 60 MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT YPPGGWDEVS 70 80 90 100 110 120 VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA QRAHIRLHFS VRACSSLGVS 130 140 150 160 170 180 GGTCRETFTL YYRQAEEPDS PDSVSSWHLK RWTKVDTIAA DESFPSSSSS SSSSSSAAWA 190 200 210 220 230 240 VGPHGAGQRA GLQLNVKERS FGPLTQRGFY VAFQDTGACL ALVAVRLFSY TCPAVLRSFA 250 260 270 280 290 300 SFPETQASGA GGASLVAAVG TCVAHAEPEE DGVGGQAGGS PPRLHCNGEG KWMVAVGGCR 310 320 330 340 350 360 CQPGYQPARG DKACQACPRG LYKSSAGNAP CSPCPARSHA PNPAAPVCPC LEGFYRASSD 370 380 390 400 410 420 PPEAPCTGPP SAPQELWFEV QGSALMLHWR LPRELGGRGD LLFNVVCKEC EGRQEPASGG 430 440 450 460 470 480 GGTCHRCRDE VHFDPRQRGL TESRVLVGGL RAHVPYILEV QAVNGVSELS PDPPQAAAIN 490 500 510 520 530 540 VSTSHEVPSA VPVVHQVSRA SNSITVSWPQ PDQTNGNILD YQLRYYDQAE DESHSFTLTS 550 560 570 580 590 600 ETNTATVTQL SPGHIYGFQV RARTAAGHGP YGGKVYFQTL PQGELSSQLP ERLSLVIGSI 610 620 630 640 650 660 LGALAFLLLA AITVLAVVFQ RKRRGTGYTE QLQQYSSPGL GVKYYIDPST YEDPCQAIRE 670 680 690 700 710 720 LAREVDPAYI KIEEVIGTGS FGEVRQGRLQ PRGRREQTVA IQALWAGGAE SLQMTFLGRA 730 740 750 760 770 780 AVLGQFQHPN ILRLEGVVTK SRPLMVLTEF MELGPLDSFL RQREGQFSSL QLVAMQRGVA 790 800 810 820 830 840 AAMQYLSSFA FVHRSLSAHS VLVNSHLVCK VARLGHSPQG PSCLLRWAAP EVIAHGKHTT 850 860 870 880 890 900 SSDVWSFGIL MWEVMSYGER PYWDMSEQEV LNAIEQEFRL PPPPGCPPGL HLLMLDTWQK 910 920 930 940 950 960 DRARRPHFDQ LVAAFDKMIR KPDTLQAGGD PGERPSQALL TPVALDFPCL DSPQAWLSAI 970 980 990 1000 1010 1020 GLECYQDNFS KFGLCTFSDV AQLSLEDLPA LGITLAGHQK KLLHHIQLLQ QHLRQQGSVE V

CATM prediction

The sequence of EPHB6_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          600       610      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 RLSLVIGSILGALAFLLLAAITVLAVV 6.4 -47.9° 0.5 47.0 -36.3
Model 2 RLSLVIGSILGALAFLLLAAITVLAVV 6.7 -52.7° 1.9 44.9 -32.0
Model 3 RLSLVIGSILGALAFLLLAAITVLAVV 6.8 -32.0° 5.8 44.0 -19.9
Model 4 RLSLVIGSILGALAFLLLAAITVLAVV 7.0 +54.1° 3.3 80.0 -14.5
Model 5 RLSLVIGSILGALAFLLLAAITVLAVV 7.4 -54.0° 3.6 49.0 -3.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 598, GLY, HA1 A, 595, LEU, O 2.55Å
B, 599, SER, HA A, 598, GLY, O 2.57Å
B, 602, GLY, HA1 A, 599, SER, O 3.40Å
A, 598, GLY, HA1 B, 595, LEU, O 2.55Å
A, 599, SER, HA B, 598, GLY, O 2.57Å
A, 602, GLY, HA1 B, 599, SER, O 3.40Å