UniProt data
UniProt name: PGRC2_HUMAN (O15173)
Gene name: PGRMC2; Synonyms=DG6, PMBP
Organism: Homo sapiens (Human).
Function: Receptor for steroids. {ECO:0000305}.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 42-66, 25 AA, Helical. {ECO:0000255}.
Sequence: 223 AA
10 20 30 40 50 60
MAAGDGDVKL GTLGSGSESS NDGGSESPGD AGAAAEGGGW AAAALALLTG GGEMLLNVAL
70 80 90 100 110 120
VALVLLGAYR LWVRWGRRGL GAGAGAGEES PATSLPRMKK RDFSLEQLRQ YDGSRNPRIL
130 140 150 160 170 180
LAVNGKVFDV TKGSKFYGPA GPYGIFAGRD ASRGLATFCL DKDALRDEYD DLSDLNAVQM
190 200 210 220
ESVREWEMQF KEKYDYVGRL LKPGEEPSEY TDEEDTKDHN KQD
CATM prediction
The sequence of PGRC2_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 40 50 60 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GWAAAALALLTGGGEMLLNVALVALVLLGAY | 6.6 | -54.9° | 1.5 | 45.1 | -31.1 |
| Model 2 | GWAAAALALLTGGGEMLLNVALVALVLLGAY | 7.1 | -37.9° | 5.7 | 34.2 | -27.6 |
| Model 3 | GWAAAALALLTGGGEMLLNVALVALVLLGAY | 7.4 | -22.2° | 3.1 | 40.0 | -13.4 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 47, LEU, HA | A, 46, ALA, O | 3.12Å |
| B, 50, GLY, HA1 | A, 47, LEU, O | 2.52Å |
| B, 51, GLY, HA2 | A, 50, GLY, O | 3.10Å |
| A, 47, LEU, HA | B, 46, ALA, O | 3.12Å |
| A, 50, GLY, HA1 | B, 47, LEU, O | 2.52Å |
| A, 51, GLY, HA2 | B, 50, GLY, O | 3.10Å |
