Tumor necrosis factor receptor superfamily member 13B

UniProt data

UniProt name: TR13B_HUMAN (O14836)

Gene name: TNFRSF13B; Synonyms=TACI

Organism: Homo sapiens (Human).

Function: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. {ECO:0000269|PubMed:10956646, ECO:0000269|PubMed:10973284}.

Subcellular location: Membrane; Single-pass type III membrane protein.

Transmembrane domains:

  1. 166-186, 21 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 293 AA

10 20 30 40 50 60 MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR 70 80 90 100 110 120 TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR 130 140 150 160 170 180 QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV ALVYSTLGLC LCAVLCCFLV 190 200 210 220 230 240 AVACFLKKRG DPCSCQPRSR PRQSPAKSSQ DHAMEAGSPV STSPEPVETC SFCFPECRAP 250 260 270 280 290 TQESAVTPGT PDPTCAGRWG CHTRTTVLQP CPHIPDSGLG IVCVPAQEGG PGA

CATM prediction

The sequence of TR13B_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         170       180       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 VYSTLGLCLCAVLCCFLVAVACFLKKR 7.1 -41.0° 3.5 38.0 -6.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session