Neuropilin-1

UniProt data

UniProt name: NRP1_HUMAN (O14786)

Gene name: NRP1; Synonyms=NRP, VEGF165R

Organism: Homo sapiens (Human).

Function: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 857-879, 23 AA, Helical. {ECO:0000255}.

Sequence: 923 AA

10 20 30 40 50 60 MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA 70 80 90 100 110 120 PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR GKFCGKIAPP PVVSSGPFLF 130 140 150 160 170 180 IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTTPSGVIKS PGFPEKYPNS LECTYIVFVP 190 200 210 220 230 240 KMSEIILEFE SFDLEPDSNP PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS 250 260 270 280 290 300 GILSMVFYTD SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN 310 320 330 340 350 360 WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYKI 370 380 390 400 410 420 DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI TRFVRIKPAT WETGISMRFE 430 440 450 460 470 480 VYGCKITDYP CSGMLGMVSG LISDSQITSS NQGDRNWMPE NIRLVTSRSG WALPPAPHSY 490 500 510 520 530 540 INEWLQIDLG EEKIVRGIII QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF 550 560 570 580 590 600 EGNNNYDTPE LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV 610 620 630 640 650 660 DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC EFGWGSHKTF 670 680 690 700 710 720 CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQNSAH 730 740 750 760 770 780 CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI 790 800 810 820 830 840 FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD 850 860 870 880 890 900 KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 910 920 FELVDGVKLK KDKLNTQSTY SEA

CATM prediction

The sequence of NRP1_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        860       870       880
 +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LDAILITIIAMSALGVLLGAVCGVVLYCA 6.3 -36.0° 2.4 59.1 -48.1
Model 2 LDAILITIIAMSALGVLLGAVCGVVLYCA 6.6 -47.9° 0.7 54.3 -38.7
Model 3 LDAILITIIAMSALGVLLGAVCGVVLYCA 6.3 -51.9° 1.3 57.0 -35.9
Model 4 LDAILITIIAMSALGVLLGAVCGVVLYCA 7.4 -41.3° 3.4 38.4 -30.3
Model 5 LDAILITIIAMSALGVLLGAVCGVVLYCA 6.8 -55.0° 4.2 37.9 -23.9
Prolines* LDPILITIIAMSALGVLLGAVCGVVLYCA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 868, GLY, HA1 A, 865, SER, O 3.18Å
B, 869, VAL, HA A, 868, GLY, O 2.27Å
B, 872, GLY, HA1 A, 869, VAL, O 2.61Å
B, 873, ALA, HA A, 872, GLY, O 2.91Å
A, 868, GLY, HA1 B, 865, SER, O 3.18Å
A, 869, VAL, HA B, 868, GLY, O 2.27Å
A, 872, GLY, HA1 B, 869, VAL, O 2.61Å
A, 873, ALA, HA B, 872, GLY, O 2.91Å