Tumor necrosis factor receptor superfamily member 10B

UniProt data

UniProt name: TR10B_HUMAN (O14763)

Gene name: TNFRSF10B; Synonyms=DR5, KILLER, TRAILR2, TRICK2, ZTNFR9

Organism: Homo sapiens (Human).

Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 211-231, 21 AA, Helical. {ECO:0000255}.

Sequence: 440 AA

10 20 30 40 50 60 MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD 70 80 90 100 110 120 LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 130 140 150 160 170 180 SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 190 200 210 220 230 240 KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV 250 260 270 280 290 300 LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 310 320 330 340 350 360 NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK 370 380 390 400 410 420 LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED 430 HLLSSGKFMY LEGNADSAMS

CATM prediction

The sequence of TR10B_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    210       220       230  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ACSLSGIIIGVTVAAVVLIVAVFVCKS 6.4 -47.0° 3.3 53.8 -30.8
Model 2 ACSLSGIIIGVTVAAVVLIVAVFVCKS 7.3 -18.0° 3.0 43.0 -28.8
Model 3 ACSLSGIIIGVTVAAVVLIVAVFVCKS 6.7 -32.0° 2.2 53.0 -27.0
Model 4 ACSLSGIIIGVTVAAVVLIVAVFVCKS 6.8 -46.0° 2.7 47.0 -11.9
Prolines* PCSLSGIIIGVTVAAVVLIVAVFVCKS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 214, ILE, HA A, 213, GLY, O 2.41Å
B, 217, GLY, HA1 A, 214, ILE, O 2.57Å
B, 218, VAL, HA A, 217, GLY, O 3.46Å
A, 214, ILE, HA B, 213, GLY, O 2.41Å
A, 217, GLY, HA1 B, 214, ILE, O 2.57Å
A, 218, VAL, HA B, 217, GLY, O 3.46Å