Receptor-type tyrosine-protein phosphatase T

UniProt data

UniProt name: PTPRT_HUMAN (O14522)

Gene name: PTPRT; Synonyms=KIAA0283

Organism: Homo sapiens (Human).

Function: May be involved in both signal transduction and cellular adhesion in the CNS.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 748-768, 21 AA, Helical. {ECO:0000255}.

Sequence: 1441 AA

10 20 30 40 50 60 MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN GFTWEQINTW 70 80 90 100 110 120 EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT HCIDFHYYFS SRDRSSPGAL 130 140 150 160 170 180 NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE LAISTFWPHF YQVIFESVSL KGHPGYIAVD 190 200 210 220 230 240 EVRVLAHPCR KAPHFLRLQN VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT 250 260 270 280 290 300 RVVNHRRFSA TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 310 320 330 340 350 360 GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL DPDVEYEIRV 370 380 390 400 410 420 LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA RQLTLQWEPF GYAVTRCHSY 430 440 450 460 470 480 NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR GLRPFMTIRL RLLLSNPEGR MESEELVVQT 490 500 510 520 530 540 EEDVPGAVPL ESIQGGPFEE KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG 550 560 570 580 590 600 KVFKLRNETH HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 610 620 630 640 650 660 NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV SYRNASSLDS 670 680 690 700 710 720 LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS YSIYFQALSK ANGETKINCV 730 740 750 760 770 780 RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV IAGLLMFIII LLGVMLTIKR RRNAYSYSYY 790 800 810 820 830 840 LKLAKKQKET QSGAQREMGP VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ 850 860 870 880 890 900 PTLTIQTHPY RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ 910 920 930 940 950 960 TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG YHRPRHYIAT 970 980 990 1000 1010 1020 QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY WPDDTEVYGD IKVTLIETEP 1030 1040 1050 1060 1070 1080 LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI 1090 1100 1110 1120 1130 1140 VVHCSAGAGR TGCFIAIDTM LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI 1150 1160 1170 1180 1190 1200 LEACLCGNTA IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP 1210 1220 1230 1240 1250 1260 RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ HPLPNTVADF 1270 1280 1290 1300 1310 1320 WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ VEFVSADIDE DIIHRIFRIC 1330 1340 1350 1360 1370 1380 NMARPQDGYR IVQHLQYIGW PAYRDTPPSK RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN 1390 1400 1410 1420 1430 1440 GGGRSGTFCA ICSVCEMIQQ QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F

CATM prediction

The sequence of PTPRT_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       750       760       77
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 VKMAGVIAGLLMFIIILLGVMLTIKRR 7.5 -39.0° 2.7 44.0 -3.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session