Pro-neuregulin-2, membrane-bound isoform

UniProt data

UniProt name: NRG2_HUMAN (O14511)

Gene name: NRG2; Synonyms=NTAK

Organism: Homo sapiens (Human).

Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Subcellular location: Neuregulin-2: Secreted {ECO:0000250}.

Transmembrane domains:

  1. 406-426, 21 AA, Helical; Note=Internal signal sequence. {ECO:0000255}.

Sequence: 850 AA

10 20 30 40 50 60 MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 70 80 90 100 110 120 APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 130 140 150 160 170 180 QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 190 200 210 220 230 240 SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 250 260 270 280 290 300 KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 310 320 330 340 350 360 VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 370 380 390 400 410 420 YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQKAEE LYQKRVLTIT GICVALLVVG 430 440 450 460 470 480 IVCVVAYCKT KKQRKQMHNH LRQNMCPAHQ NRSLANGPSH PRLDPEEIQM ADYISKNVPA 490 500 510 520 530 540 TDHVIRRETE TTFSGSHSCS PSHHCSTATP TSSHRHESHT WSLERSESLT SDSQSGIMLS 550 560 570 580 590 600 SVGTSKCNSP ACVEARARRA AAYNLEERRR ATAPPYHDSV DSLRDSPHSE RYVSALTTPA 610 620 630 640 650 660 RLSPVDFHYS LATQVPTFEI TSPNSAHAVS LPPAAPISYR LAEQQPLLRH PAPPGPGPGP 670 680 690 700 710 720 GPGPGPGADM QRSYDSYYYP AAGPGPRRGT CALGGSLGSL PASPFRIPED DEYETTQECA 730 740 750 760 770 780 PPPPPRPRAR GASRRTSAGP RRWRRSRLNG LAAQRARAAR DSLSLSSGSG GGSASASDDD 790 800 810 820 830 840 ADDADGALAA ESTPFLGLRG AHDALRSDSP PLCPAADSRT YYSLDSHSTR ASSRHSRGPP PRAKQDSAPL

CATM prediction

The sequence of NRG2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         410       420       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 QKRVLTITGICVALLVVGIVCVVAYCK 7.2 -47.1° 1.3 45.1 -12.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 408, THR, HA A, 407, LEU, O 3.43Å
B, 411, GLY, HA1 A, 408, THR, O 3.05Å
B, 412, ILE, HA A, 411, GLY, O 3.23Å
A, 408, THR, HA B, 407, LEU, O 3.43Å
A, 411, GLY, HA1 B, 408, THR, O 3.05Å
A, 412, ILE, HA B, 411, GLY, O 3.23Å