Beta-1,3-N-acetylglucosaminyltransferase manic fringe

UniProt data

UniProt name: MFNG_HUMAN (O00587)

Gene name: MFNG

Organism: Homo sapiens (Human).

Function: Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. {ECO:0000269|PubMed:10935626}.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 8-27, 20 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 321 AA

10 20 30 40 50 60 MQCRLPRGLA GALLTLLCMG LLCLRYHLNL SPQRVQGTPE LSQPNPGPPK LQLHDVFIAV 70 80 90 100 110 120 KTTRAFHRLR LELLLDTWVS RTREQTFVFT DSPDKGLQER LGSHLVVTNC SAEHSHPALS 130 140 150 160 170 180 CKMAAEFDTF LASGLRWFCH VDDDNYVNPR ALLQLLRAFP LARDVYVGRP SLNRPIHASE 190 200 210 220 230 240 PQPHNRTRLV QFWFATGGAG FCINRKLALK MAPWASGSRF MDTSALIRLP DDCTMGYIIE 250 260 270 280 290 300 CKLGGRLQPS PLFHSHLETL QLLRTAQLPE QVTLSYGVFE GKLNVIKLQG PFSPEEDPSR 310 320 FRSLHCLLYP DTPWCPQLGA R

CATM prediction

The sequence of MFNG_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       10        20        3
+    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 LARGLAGALLTLLCMGLLCLRYHLNL 6.9 -39.7° 4.1 37.9 -5.6
Prolines* LPRGLAGALLTLLCMGLLCLRYHLNL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 11, GLY, HA1 A, 8, GLY, O 2.85Å
B, 12, ALA, HA A, 11, GLY, O 3.47Å
B, 12, ALA, HA A, 15, THR, OG1 2.44Å
A, 11, GLY, HA1 B, 8, GLY, O 2.85Å
A, 12, ALA, HA B, 11, GLY, O 3.47Å
A, 12, ALA, HA B, 15, THR, OG1 2.44Å