Uroplakin-2

UniProt data

UniProt name: UPK2_HUMAN (O00526)

Gene name: UPK2

Organism: Homo sapiens (Human).

Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.

Transmembrane domains:

  1. 156-176, 21 AA, Helical. {ECO:0000255}.

Sequence: 184 AA

10 20 30 40 50 60 MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL 70 80 90 100 110 120 MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL 130 140 150 160 170 180 VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL GSRK

CATM prediction

The sequence of UPK2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         160       170       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 TGGMVVITVLLSVAMFLLVLGFIIALA 7.3 -43.9° 0.9 45.8 -15.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 173, GLY, HA1 A, 170, LEU, O 3.36Å
B, 174, PHE, HA A, 173, GLY, O 3.38Å
A, 173, GLY, HA1 B, 170, LEU, O 3.36Å
A, 174, PHE, HA B, 173, GLY, O 3.38Å