Butyrophilin subfamily 3 member A3

UniProt data

UniProt name: BT3A3_HUMAN (O00478)

Gene name: BTN3A3; Synonyms=BTF3

Organism: Homo sapiens (Human).

Function: Plays a role in T-cell responses in the adaptive immune response. {ECO:0000269|PubMed:22767497}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}; Single-pass type I membrane protein {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.

Transmembrane domains:

  1. 249-269, 21 AA, Helical. {ECO:0000255}.

Sequence: 584 AA

10 20 30 40 50 60 MKMASSLAFL LLNFHVSLFL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 70 80 90 100 110 120 ETMELRWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 130 140 150 160 170 180 SGKYLCYFQD GDFYEKALVE LKVAALGSDL HIEVKGYEDG GIHLECRSTG WYPQPQIKWS 190 200 210 220 230 240 DTKGENIPAV EAPVVADGVG LYAVAASVIM RGSSGGGVSC IIRNSLLGLE KTASISIADP 250 260 270 280 290 300 FFRSAQPWIA ALAGTLPISL LLLAGASYFL WRQQKEKIAL SRETEREREM KEMGYAATEQ 310 320 330 340 350 360 EISLREKLQE ELKWRKIQYM ARGEKSLAYH EWKMALFKPA DVILDPDTAN AILLVSEDQR 370 380 390 400 410 420 SVQRAEEPRD LPDNPERFEW RYCVLGCENF TSGRHYWEVE VGDRKEWHIG VCSKNVERKK 430 440 450 460 470 480 GWVKMTPENG YWTMGLTDGN KYRALTEPRT NLKLPEPPRK VGIFLDYETG EISFYNATDG 490 500 510 520 530 540 SHIYTFPHAS FSEPLYPVFR ILTLEPTALT ICPIPKEVES SPDPDLVPDH SLETPLTPGL 550 560 570 580 ANESGEPQAE VTSLLLPAHP GAEVSPSATT NQNHKLQART EALY

CATM prediction

The sequence of BT3A3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      250       260       270
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 QAWIAALAGTLAISLLLLAGASYFLWR 7.2 -46.2° 4.7 38.0 -11.3
Prolines* QPWIAALAGTLPISLLLLAGASYFLWR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 251, ALA, HA A, 250, ALA, O 3.09Å
B, 254, GLY, HA1 A, 251, ALA, O 3.39Å
A, 251, ALA, HA B, 250, ALA, O 3.09Å
A, 254, GLY, HA1 B, 251, ALA, O 3.39Å