UniProt data
UniProt name: LST1_HUMAN (O00453)
Gene name: LST1; Synonyms=B144
Organism: Homo sapiens (Human).
Function: Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. {ECO:0000269|PubMed:10706707, ECO:0000269|PubMed:11478849}.
Subcellular location: Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Transmembrane domains:
- 8-28, 21 AA, Helical. {ECO:0000255}.
Sequence: 97 AA
CATM prediction
The sequence of LST1_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 10 20 30 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | NDDICIYGGLGLGGLLLLAVVLLSACL | 7.3 | -46.2° | 2.7 | 47.1 | -15.2 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 10, ILE, HA | A, 9, CYS, O | 3.33Å |
| B, 13, GLY, HA1 | A, 10, ILE, O | 3.28Å |
| A, 10, ILE, HA | B, 9, CYS, O | 3.33Å |
| A, 13, GLY, HA1 | B, 10, ILE, O | 3.28Å |