Synaptotagmin-5

UniProt data

UniProt name: SYT5_HUMAN (O00445)

Gene name: SYT5

Organism: Homo sapiens (Human).

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). {ECO:0000250}.

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In mast cells, localizes to the endocytic recycling compartment. {ECO:0000250}.

Transmembrane domains:

  1. 25-45, 21 AA, Helical. {ECO:0000255}.

Sequence: 386 AA

10 20 30 40 50 60 MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL YRKSCRRRTG 70 80 90 100 110 120 KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG QQVADKHELG RLQYSLDYDF 130 140 150 160 170 180 QSGQLLVGIL QAMGLAALDL GGSSDPYVRV YLLPDKRRRY ETKVHRQTLN PHFGETFAFK 190 200 210 220 230 240 VPYVELGGRV LVMAVYDFDR FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL 250 260 270 280 290 300 GDICFSLRYV PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN 310 320 330 340 350 360 TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG GAGLRHWADM 370 380 LANPRRPIAQ WHSLRPPDRV RLLPAP

CATM prediction

The sequence of SYT5_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          30        40       
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 ISHGAVAAWALATIVLVSGLLIFSCCF 7.0 -38.0° 5.7 34.0 -5.4
Model 2 ISHGAVAAWALATIVLVSGLLIFSCCF 7.1 -51.0° 6.0 45.0 -1.7
Prolines* ISHGPVPPWALATIVLVSGLLIFSCCF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 26, ALA, HA A, 25, GLY, O 3.00Å
A, 26, ALA, HA B, 25, GLY, O 3.00Å