UniProt data
UniProt name: TGR3L_HUMAN (H3BV60)
Gene name: TGFBR3L
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 269-289, 21 AA, Helical. {ECO:0000255}.
Sequence: 316 AA
10 20 30 40 50 60
MGESAAATAS LFQRRRRGRG GRVTFPGGLK GSARFLSFGP PFPAPPAPPF PAAPGPWLRR
70 80 90 100 110 120
PLFSLKLSDT EDVFPRRAGP LEVPADSRVF VQAALARPSP RWGLALHRCS VTPSSRPAPG
130 140 150 160 170 180
PALALLREGC PADTSVAFPP PPPPSPGAAR PARFSFRLRP VFNASVQFLH CQLSRCRRLR
190 200 210 220 230 240
GVRRAPAPLT PPPPPPPSRC LPQDEACADT GSGSAEGLAA DGPHLHTLTQ PIVVTVPRPP
250 260 270 280 290 300
PRPPKSVPGR AVRPEPPAPA PAALEPAPVV ALVLAAFVLG AALAAGLGLV CAHSAPHAPG
310
PPARASPSGP QPRRSQ
CATM prediction
The sequence of TGR3L_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 270 280 290 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | AAAVVALVLAAFVLGAALAAGLGLVCA | 6.8 | -43.3° | 2.4 | 44.0 | -31.3 |
| Model 2 | AAAVVALVLAAFVLGAALAAGLGLVCA | 7.4 | -54.1° | 3.6 | 49.0 | -5.1 |
| Model 3 | AAAVVALVLAAFVLGAALAAGLGLVCA | 6.9 | -43.0° | -0.0 | 34.1 | -2.8 |
| Prolines* | PAPVVALVLAAFVLGAALAAGLGLVCA |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 277, PHE, HA | A, 276, ALA, O | 2.83Å |
| B, 280, GLY, HA1 | A, 277, PHE, O | 2.73Å |
| B, 281, ALA, HA | A, 280, GLY, O | 3.13Å |
| A, 277, PHE, HA | B, 276, ALA, O | 2.83Å |
| A, 280, GLY, HA1 | B, 277, PHE, O | 2.73Å |
| A, 281, ALA, HA | B, 280, GLY, O | 3.13Å |
